Apologies for another post. Just wondering how quickly people have found biologics take to start working? I ask because - as you probably have seen - I only injected Adalimumab for the very first time just over 48 hours ago, and today I am feeling massively better, to a quite ridiculous degree. Surely this is too fast for it to be the biologics? Placebo effect, maybe? Steroids starting to work again despite having been reducing the dose? Or CAN they work that quickly?! The leaflet reckoned two weeks was possible, but two days..?
Either way, it certainly was a nice surprise to find myself trotting downstairs like a 38 rather than a 98 year old this morning!
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Smelliott
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When I started Humira (Adalimumab) I felt better within a week. Unfortunately I had to come off of that and now I’m on Benepali and that took nearly a year to work and only then with methotrexate added in. Good luck with Adalimumab.
Enbrel took two hours to work for me. Sadly stopped working after five weeks but shows how they can be very quick.
Mine worked within days by a few weeks I was doing great . I have heard people say it worked almost straight away then others said it worked quickly but didn’t last and others were slow burners slowly slowly improved then a few months later they were flying. We are all different.. boy am I happy for you 🤞it continues
When I was on Adalimumab, I was in the 'slow burner' category. However, I had to laugh when I read your post as, similarly to you, one day, I found myself running up the stairs, something that I hadn't done in years! As others have noted, apparently for some people, the drug can work in an incredibly short period of time. All the best for continued good effects!
Oh wow, you have given me hope!!! Thank you for sharing your experience. Don't look a gift improvement in the mouth 😁 I hope when I start Adalimumab next week I have the same good luck.
When I injected Enbrel for the first time, I started feeling relief that first night. It was a tremendous feeling. I know others don’t, but I really did. I was only upset I waited so long to start on it!
I hope you found something else! Enbrel Yeah, got me out of a total tailspin, but it was RoActemra my current med that did the trick about 9 months later :).
That’s Tocilizumab? Thank you. I’m doing well on Rituximab infusions. Glad you are on your med. I know very little other about yours other than it works great for so many and gives them their life back after several failed meds. It was a consideration for a little while for me but my rheumy said I had to go for Rituximab in early 2014 and that worked really well after 6 weeks. Some take longer and patience is needed.
I started Adalimumab around 9 months ago and felt improvement within 24 hours but it didn’t last through to the next injection 2 weeks later. It took about 4 injections (8weeks) for the improvement to last .... but haven’t looked back since. It’s worked brilliantly for me so far 👍🤞🤞
Unfortunately, no, it failed after 3 months. However, am now on another biologic and MTX and doing OK. Failure of the first one may have been linked to the fact that I had to leave it off for several doses because of a persistent infection requiring antibiotics. Rheumy told me that they know that a percentage of people who have to leave their biologic off for a period of time, e.g. pregnant women, no longer respond to the biologic when it is reinstated. So, drink plenty to avoid any UTI's. Good luck. 🙂
That's terrible, I'm in remission thanks to enbrel and I refused to switch, typed up notes detailing why and thankfully was able to stay on enbrel. I've been in remission since early 2013.
I felt better with humira after three weeks I was on the jab for many years but had to come off it as just as it started it stopped just as quickly. But whilst it lasts fantastic 🌺
I'm on enbrel and I can honestly say I felt it work the next day, twelve weeks later was told I was in remission and still am, that was early 2013. No pain relief required and no side effects. Good luck.
I was diagnosed in May 2008, I do think looking back I had had RA probably since the 90's. I'd had two bad flares in my shoulders and it was suggested to me in an out of hours doctors appointment that I could have RA, the pain I was in was horrendous. Once it had settled down I just got on with life and had the odd pain and stiffness here and there but put it down to getting older.
In March 2008 things started to kick off bad. My GP was useless and I ended up going private. Once diagnosed I was put on slz, then two years later I had mtx added. In the summer of 2012 I was really, bad. Had an emergency appointment at the hospital, my das score that day was 7.2 which is very high disease activity, (5.1 or above is a high score), I was given a steroid injection that day which is not the norm when your being assessed for anti tnfs. At my second assessment even with having a steroid injection five weeks earlier my Das score was 5.9, I had qualified for anti tnfs.
I didn't start enbrel until November 2012, by this time I was the worse I'd ever been, heaven knows what my das score would of been. Like I said in my previous post enbrel started working it's magic the day after my first injection and in feb 2013 was told I was in remission, that quick! I call enbrel my magic potion.
This is great news for you, when I started Cimzia I was just like you it took affect very quickly, I reduced my MTX to 4 tablets & no other steroids or paracetamol was needed, it just all worked for me it was the 1st biologic I went on & had a good run on it for about 5 yrs. I hope you continue to have positive results, I genuinely wouldn’t of known I had RA at that time. Good luck & long may it continue..
Yes it can work quickly I’ve not actually had a biologic but when I first had a Jak inhibitor (baricitinib) I felt the inflammation reducing in my knees within a few days. So sad it had to be stopped and didn’t really get the chance of putting me in remission as I had to keep coming off it due to infections. Was great improvement for a while though. Good luck and I doubt it’s a placebo effect but as others have said take it easy and don’t overdo it to start with because it will bite you if you do. Easy to say hard to do.
Wow, thanks for all the replies! You lot are the best.
Yes. My joint pain eased very quickly, in a week. Then 2-3 weeks and my skin completely cleared and I had patches of inflamed psoriasis on all joints, skin folds which was horrifically painful and upsetting.
Been on imraldi 2 years and had no joint pain or psoriasis in that time.
Yes- like previous poster, I was astounded to find myself running up the stairs!
Sadly my joint pain is returning in my hands and it may be losing its effectiveness for me, but I've tended to just get 2-3 years with treatments.
Overall imraldi really helped me and I've had a life for the past two years - despite pandemic/lockdown which feels bizarre but there you go. Health is everything. Imraldi has been great. All the best.
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