I have a seronegative inflammatory arthritis and I'm in my 30s. I was initially put on hydroxychloroquine and it made a huge difference for me at first. Last year, after about a year on it, I had a worsening of joint symptoms during a time of acute stress and was put on sulfasalazine and the HCQ was reduced. I was told I might have psoriatic arthritis (I don't have any skin psoriasis but I do have mild nail pitting).
I had really horrible side effects from the sulfasalazine at first but they settled down. I also had a rash but it only lasted 48 hours.
After a few months on the sulfasalazine I can't say I've noticed much improvement. I also think my mood has been very low and I'm concerned that the drug is to blame.
I had POTS in the past but it resolved last year. Now it's returned. I also have some digital ulcers and raynaud's-type symptoms.
I was really pinning my hopes on the sulfasalazine but it's done nothing really. If anything I feel worse.
I have given it more than 3 months now and I'm prepared to quit. I see my consultant soon and I just don't know what the next step is. Methotrexate has been mentioned but the thought of working full-time with those side effects terrifies me.
Plus, I don't really know what is wrong. I have obvious joint problems. I'm pretty sure it's not RA, and I can see why they think it's PsA. But I don't have psoriasis and hydroxychloroquine shouldn't have helped so much for PsA should it? And there are other unexplained symptoms that point more towards something else. And I used to get nasal ulcers which have disappeared since being on hydroxychloroquine. But my ANA test was negative when I had it 3 years ago.
I don't know where to turn next, what to ask the doctor, what to expect. I just want my old body back. I need to make the most of my upcoming appointment so really any thoughts would be welcome. X