I’ve been lucky with Methotrexate, with pretty much no side effects apart from a little nausea when I started on it which was corrected by increasing my folic acid to three times a week. I take it by injection and it has done wonders for my RA.
However, my previous consultant felt the dose should be increased from 15mg to 20mg, presumably because of the long term risks of ongoing inflammation. I tried unsuccessfully to discuss possible increased side effects with him but he didn’t seem to see discussion as part of his role...I’m now going to see a new consultant at a different hospital and wondered if anyone knows of any research/info on the extent to which side effects of Mtx can increase with an increase in dose? Presumably it’s a very individual thing and a bit of a grey area?