I've been on humira for 2.5 years. It's working quite well and I certainly wouldn't want to stop taking it. I inject every other Thursday evening. I inject methotrexate (17.5mg) every Friday evening. I've noticed that the weeks I have both injections, I am completely and utterly wiped out the entire weekend. Bizarrely, I can never sleep the night of the humira injection and this is so unlike me. I wonder if I should try humira on Thursday morning instead? Insomnia is not the most common side effect but apparently, it's not unheard of either. I'm trying to balance having good disease control without being totally annihilated by the medications. Any ideas would be gratefully received, please and thank you.