Hi, Was diagnosed as sero negative arthritis about six years ago, and have been reducing Methotrexate from 10 tablets to 4 gradually. I have been on the reduced dose of 4 for about six weeks now, and although blood shows normal CRP levels, I am experiencing same symptoms as when first diagnosed, and feeling unwell. The symptoms I first started with was uncontrollable neck pain despite pain relief and this has returned, along with niggles of other joints. Has anyone else had this experience of normal inflammatory levels, but arthritic symptoms of pain? I remain on all other medication, Sulphasalazine and Hydroxychloroquine.