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Nilutamide
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Enzalutamide & 5-year survival in mHSPC.
"Patients in the ENZAMET trial (n = 1125) were randomized 1:1 to arm A, the control arm consisting of TS plus a standard non-steroidal antiandrogen ([NSAA] bicalutamide,
nilutamide
, or flutamide), or enzalutamide at 160 mg per day plus TS in arm B. " "The 5-year OS rates were 81% and 66% for those with
"Patients in the ENZAMET trial (n = 1125) were randomized 1:1 to arm A, the control arm consisting of TS plus a standard non-steroidal antiandrogen ([NSAA] bicalutamide,
nilutamide
, or flutamide), or enzalutamide at 160 mg per day plus TS in arm B. " "The 5-year OS rates were 81% and 66% for those with
pca2004
in
Fight Prostate Cancer
11 months ago
More on abiraterone prices
Seems to imply that the only ones you really need are bicalutamide or
nilutamide
(!).
Seems to imply that the only ones you really need are bicalutamide or
nilutamide
(!).
Gearhead
in
Advanced Prostate Cancer
1 year ago
Eligard for me= poison
When getting Eligard shots after prostatectomy and radiation it was holding PSA level down. It also turned my thoughts angry and disgruntled. Doctor Larock from Mattapoisett is treating me with Flutamide and Bicalutimide 1 pill day each. Thanks Jesus I can write this and feel pretty good for 75. Eligard
When getting Eligard shots after prostatectomy and radiation it was holding PSA level down. It also turned my thoughts angry and disgruntled. Doctor Larock from Mattapoisett is treating me with Flutamide and Bicalutimide 1 pill day each. Thanks Jesus I can write this and feel pretty good for 75. Eligard
Shorttimer
in
Advanced Prostate Cancer
10 months ago
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Final STAMPEDE results for Abi with/out Enza when starting ADT.
New paper below [1]. "Between Nov 15, 2011, and Jan 17, 2014, 1003 patients were randomly assigned to standard of care (n=502) or standard of care plus abiraterone (n=501) in the abiraterone trial. "Between July 29, 2014, and March 31, 2016, 916 patients were randomly assigned to standard of care
New paper below [1]. "Between Nov 15, 2011, and Jan 17, 2014, 1003 patients were randomly assigned to standard of care (n=502) or standard of care plus abiraterone (n=501) in the abiraterone trial. "Between July 29, 2014, and March 31, 2016, 916 patients were randomly assigned to standard of care
pca2004
in
Fight Prostate Cancer
1 year ago
Androgen receptor mutations for precision medicine in prostate cancer - Endocrine-Related Cancer, Review Article, Published: 17 Aug 2022
This is a very informative research paper on the mechanisms involved with current treatments that target the AR in PCa. Interestingly, it compares/contrast the actions (both as agonistic and antagonistic) of the ADT drugs (Bicalutamid, Flutamide, Enzalutamide, Apalutamide, Darolutamide, & Hydrocortisone
This is a very informative research paper on the mechanisms involved with current treatments that target the AR in PCa. Interestingly, it compares/contrast the actions (both as agonistic and antagonistic) of the ADT drugs (Bicalutamid, Flutamide, Enzalutamide, Apalutamide, Darolutamide, & Hydrocortisone
cujoe
in
Fight Prostate Cancer
2 years ago
A very cool link for all inhibitors that you can download
Here is a very cool link on all the inhibitors. This link is awesome and it covers all inhibitors for all of the cancer pathways. Half way down under "Other Androgen Receptor Products" you will see two graphics; one is "Download Inhibitor Catalog", the other is download the "Androgen Receptor Signaling
Here is a very cool link on all the inhibitors. This link is awesome and it covers all inhibitors for all of the cancer pathways. Half way down under "Other Androgen Receptor Products" you will see two graphics; one is "Download Inhibitor Catalog", the other is download the "Androgen Receptor Signaling
KocoPr
in
Advanced Prostate Cancer
2 years ago
Latest from BATman Denmeade
Antiandrogens include bicalutamide (Casodex),
nilutamide
(Nilandron), enzalutamide (Xtandi), apalutamide (Erleada), and darolutamide (Nubeqa). PSA, prostate-specific antigen. [Color figure can be viewed at wileyonlinelibrary.com] 2.3 Why does prostate cancer become castration resistant?
Antiandrogens include bicalutamide (Casodex),
nilutamide
(Nilandron), enzalutamide (Xtandi), apalutamide (Erleada), and darolutamide (Nubeqa). PSA, prostate-specific antigen. [Color figure can be viewed at wileyonlinelibrary.com] 2.3 Why does prostate cancer become castration resistant?
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Free vs Total Testosterone? - Redux.
Cheerr had asked: "Which test is recommended for Pca patients - Total or Free." I belatedly remembered a German study [1] that took a look at the issue. This could be important - hence the new post. "Despite the fact that free testosterone (FT) is the biologically active form, it is common practice
Cheerr had asked: "Which test is recommended for Pca patients - Total or Free." I belatedly remembered a German study [1] that took a look at the issue. This could be important - hence the new post. "Despite the fact that free testosterone (FT) is the biologically active form, it is common practice
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Flutamide, bicalutamide, nilutamide, apalutamide or enzalutamide?
According to the cancer.gov fact sheet for Hormone Therapy for Prostate Cancer, there are 5 types of CAB, Complete Androgen Blockade. I've been on bical. for about 20 months. However, against advice, I have not had radiation nor surgery. The combo I'm using is finasteride, tamsulosin and bicalutamide
According to the cancer.gov fact sheet for Hormone Therapy for Prostate Cancer, there are 5 types of CAB, Complete Androgen Blockade. I've been on bical. for about 20 months. However, against advice, I have not had radiation nor surgery. The combo I'm using is finasteride, tamsulosin and bicalutamide
RICH22
in
Advanced Prostate Cancer
4 years ago
Therapies Targeted to Androgen Receptor SignalingAxis in Prostate Cancer: Progress, Challenges,and Hope - published December 2019
I was doing some research on ARL702H, which the Guardiant360 revealed for my husband. I think ARL702H is brought on from being on Zytiga + prednisone. - and this may be why switching from predisone to dexamethasone can help the Zytiga to continue working: Role of Androgen Receptor in Prostate Cancer
I was doing some research on ARL702H, which the Guardiant360 revealed for my husband. I think ARL702H is brought on from being on Zytiga + prednisone. - and this may be why switching from predisone to dexamethasone can help the Zytiga to continue working: Role of Androgen Receptor in Prostate Cancer
JLS1
in
Advanced Prostate Cancer
4 years ago
Flutamide"
New paper from Japan [1]. The antiandrogen flutamide was approved by the FDA for PCa thirty years ago. Bicalutamide had been approved by the FDA a few years earlier. The paper presents an anecdotal case of a man "in whom flutamide controlled disease progression for 10 years" "after bicalutamide failure
New paper from Japan [1]. The antiandrogen flutamide was approved by the FDA for PCa thirty years ago. Bicalutamide had been approved by the FDA a few years earlier. The paper presents an anecdotal case of a man "in whom flutamide controlled disease progression for 10 years" "after bicalutamide failure
pjoshea13
in
Advanced Prostate Cancer
4 years ago
LiverTox docs
(Textbook of pharmacology and therapeutics discusses the androgen receptor antagonists flutamide, bicalutamide,
nilutamide
and enzalutamide, but not apalutamide). https://www.accessdata.fda.gov/scripts/cder/daf/ (FDA Drug Approvals website that has product labels [package inserts], letters of approval
(Textbook of pharmacology and therapeutics discusses the androgen receptor antagonists flutamide, bicalutamide,
nilutamide
and enzalutamide, but not apalutamide). https://www.accessdata.fda.gov/scripts/cder/daf/ (FDA Drug Approvals website that has product labels [package inserts], letters of approval
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Replacement of Bicalutamide
Replacement of Bicalutamide and (God forbid a toxic
Nilutamide
). While visiting relatives in Europe my Urologist there was suggesting ; KETOCONAZOLE As a Bicalutamide replacement. I am still on 4 month LUPRON . Any experience or comment on this please. Thanks and greetings to all ! Victor
Replacement of Bicalutamide and (God forbid a toxic
Nilutamide
). While visiting relatives in Europe my Urologist there was suggesting ; KETOCONAZOLE As a Bicalutamide replacement. I am still on 4 month LUPRON . Any experience or comment on this please. Thanks and greetings to all ! Victor
Victorq1
in
Prostate Cancer Network
5 years ago
Fibrinogen
"To celebrate the [i]Prostate Cancer and Prostatic Diseases[/i] satellite meeting in Shangai on 7 December 2018, Dr Stephen Freedland and Dr Dingwei Ye selected some of our top papers from China." https://www.nature.com/documents/PCAN_Best_of_China_collection_v2.pdf I was particularly interested in
"To celebrate the [i]Prostate Cancer and Prostatic Diseases[/i] satellite meeting in Shangai on 7 December 2018, Dr Stephen Freedland and Dr Dingwei Ye selected some of our top papers from China." https://www.nature.com/documents/PCAN_Best_of_China_collection_v2.pdf I was particularly interested in
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Newbie - Introduction
My husband, age 58, was diagnosed July 2016. PSA 477, Gleason 9. Oncologist advised against any treatment. Urologist started with Firmagon, monthly. He suggested Docetaxel - oncologist later agree and chemo treatment started - treatment was tolerated well. Different treatments were introduced: Prednisone
My husband, age 58, was diagnosed July 2016. PSA 477, Gleason 9. Oncologist advised against any treatment. Urologist started with Firmagon, monthly. He suggested Docetaxel - oncologist later agree and chemo treatment started - treatment was tolerated well. Different treatments were introduced: Prednisone
Frizzee
in
Advanced Prostate Cancer
5 years ago
Hormone therapy with the lutamides and keepin your testosterone intact
We have plenty of them now. Flutamide, nylutamide, bicalutamidee, ensulutamide, ampulutamide, darolutamide. Are there any more? There are also adjuncts to these. I use avodart, some in clinical trials. I failed casodex after 7+ yrs than xtandi for a year with lupron which I think wasn't necessary since
We have plenty of them now. Flutamide, nylutamide, bicalutamidee, ensulutamide, ampulutamide, darolutamide. Are there any more? There are also adjuncts to these. I use avodart, some in clinical trials. I failed casodex after 7+ yrs than xtandi for a year with lupron which I think wasn't necessary since
rococo
in
Advanced Prostate Cancer
5 years ago
Thalidomide and Lenalidomide in metastatic PCa.
New study below. Six months back I started a thread: "Non-PCa Prescription Drugs: Thalidomide / Lenalidomide (Revlimid)" https://healthunlocked.com/advanced-prostate-cancer/posts/137369286/non-pca-prescription-drugs-thalidomide-lenalidomide-revlimid 18 months earlier, I had posted the Mainsail trial
New study below. Six months back I started a thread: "Non-PCa Prescription Drugs: Thalidomide / Lenalidomide (Revlimid)" https://healthunlocked.com/advanced-prostate-cancer/posts/137369286/non-pca-prescription-drugs-thalidomide-lenalidomide-revlimid 18 months earlier, I had posted the Mainsail trial
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Horrible horrible migraines
hello all! As some of you know, i've started taking Synthroid about a month ago (25 mcgs/ day) Still haven't gone back for my 6 weeks to potentially up the dose. I'm also taking 5000 IU of Vitamin D3 + 50 mcg of K2 every other day. I'm also supposed to start taking Flutamide (anti-androgen) for my PCOS
hello all! As some of you know, i've started taking Synthroid about a month ago (25 mcgs/ day) Still haven't gone back for my 6 weeks to potentially up the dose. I'm also taking 5000 IU of Vitamin D3 + 50 mcg of K2 every other day. I'm also supposed to start taking Flutamide (anti-androgen) for my PCOS
camilla_01
in
Thyroid UK
6 years ago
Nilutamide
Has anybody got any experience here in using
Nilutamide
? My Dad is off Casodex, because he is high risk for Casodex resistance . Currently on Degarelix and Zytiga. Any info greatly receieved.. And also, does anybody know where to source it? and dosage info? Thanks
Has anybody got any experience here in using
Nilutamide
? My Dad is off Casodex, because he is high risk for Casodex resistance . Currently on Degarelix and Zytiga. Any info greatly receieved.. And also, does anybody know where to source it? and dosage info? Thanks
taylor123
in
Advanced Prostate Cancer
6 years ago
Xtandi vs generic. Humana advised upon first prescription for Xtandi that the generic drug Flutamide is a substitute. Anyone using a generic
My insurer Humana advised on 2/23/18 that Flutamide is an “approved” generic for Xtandi. This was news to me & while I’m checking with oncologist I wanted to seek input from real world users. This generic is substantially less than Xtandi in price but more important to me is it’s effectiveness. I am
My insurer Humana advised on 2/23/18 that Flutamide is an “approved” generic for Xtandi. This was news to me & while I’m checking with oncologist I wanted to seek input from real world users. This generic is substantially less than Xtandi in price but more important to me is it’s effectiveness. I am
Jackrow
in
Advanced Prostate Cancer
6 years ago
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