Hello, I have just been prescribed orlistat by my GP as I weigh 16st 7lb and have a BMI of 39. I suffer from juvenille rheumatoid arthitis and require ankle replacements so cannot exercise much at the moment but need to reduce my weight before they will carry out the replacements. I have tried most diets, but rosemary conley and the nhs freshstart seem to work the best, but I think that was just due to the exercise I was doing at the time. I have tried to stick with the healthy eating and reducing my calories down a bit more (as advised by dietician) but have still carried on putting on a little weight. I was just wondered how you have found orlistat? I have heard you have to eat a certain amount of fat for it to work, but not too much to get the horrible side effects. I have been taking it for 3 days now and fingers crossed no side effects yet. Anyone with any info or tips they can give me?