I've had PV for eleven years and recently started on Interferon Peg. I have had two injections so far (dose 90 per week) with no improvement whatsoever. My red cell and platelet count have in fact got much worse. Is it too early for the Interferon to be having any effect? Does it take longer than this to kick in? I'm so worried that it won't work at all. Prior to Interferon I have been on Hydroxycarbamide for six years which controlled my platelets but was no longer working on my red cells, it could have also contributed to a skin cancer on my face so the decision was made to swap to Interferon. I do have a previous history of Melanoma and Basal Cell carcinoma prior to Hydroxycarbamide. I'm booked in for venesection tomorrow but this is not a long term solution for me as they really struggle to get blood out.