Hi, I am 56 year old female and I was diagnosed with PV in March this year. At first I was fine with phlebotomies and baby asperin, but in August my platelets went to 1.2 mio and the doctor told me to start Hydroxyrea, 500mg/daily. I have always exercised every day and eaten pretty healthy. lots of water. When I exercise or stand for a while my calves kind of swell up, but it does not looks like water retention. I showed the doc once and he was not concerned. Not my feet, just the legs. Have anybody ever experience that? And, will the weight gain stop at one point? I have to admit, that taking a chemo drug is making me sad, I was told I had to take it for the rest of my life. I also experience more white mucus and cough. Thank you so much for any advise.