NIH Collaboratory - Rethinking Clinical Trials

NIH Collaboratory - Rethinking Clinical Trials

The Mission: Strengthen the national capacity to implement cost-effective large-scale research studies that engage healthcare delivery organizations as research partners.

Supported by the Common Fund at the US National Institutes of Health (NIH), the NIH Health Care Systems Research Collaboratory aims to improve the way clinical trials are conducted by creating a new infrastructure for collaborative research with healthcare systems. The ultimate goal is to ensure that healthcare providers and patients can make decisions based on the best available clinical evidence.

The Collaboratory also supports the design and rapid execution of pragmatic clinical trial Demonstration Projects that address questions of major public health importance and engage healthcare delivery systems in research partnerships. These projects help to establish best practices and provide proof of concept for innovative designs in pragmatic clinical research.

Seven Cores/Working Groups, each focused on a specific topic, support all of the Demonstration Projects and initiatives across the Collaboratory.

Data, tools, and resources produced by the Collaboratory are made available to the greater research community to promote partnerships with healthcare systems and propel a transformation in how clinical research is conducted. Dissemination efforts include the Collaboratory’s Knowledge Repository, Living Textbook, and weekly Grand Rounds webinar series.


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