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Anti-dsDNA and negative ANA

Anti-dsDNA and negative ANA

Hello, all! I have many of the symptoms of Lupus(extreme fatigue, face rash, joint pain...) but my ANA came back negative twice. But my anti-dsdna came back with the results I posted below. My primary doctor scanned over all my blood results and said they looked fine, and I had to bring up the anti-DsDNA levels because he hadn’t looked at it. (I had seen the results online). He said the number didn’t seem very high, so he wasn’t worried about it.

I’ve been doing tons of research online and what I’m understanding is that the anti-dsdna shouldn’t show up at all unless SOMETHING is going on with me health wise. Maybe I’m misunderstanding. I just feel like I’ve hit a dead end and it’s upsetting. Any insight anyone may have would be helpful! If I’m overreaching or overreacting, don’t be afraid to say so! 😊 I posted my results for references.

4 Replies

Been watching the Betrayal docuseries online with Dr Tom O'Bryan. Suggestions that auto immune conditions may be brewing for years before all tests actually show positive results for one auto immune condition or another.

If you haven't come across it yet it might be worth looking for it. Many contributors from across the world including the renowned Dr Yehudi Shoenfield from Israel.

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Thank you very much for the information, I will be sure to check it out!


Some people never get the positive antibodies. Most people present in highly unique and individual ways. Also, auto immune diseases can evolve with time and follow unexpected patterns as they become more (or less) clearly differentiated.

My sero negative SLE/UCTD has been with me for nearly 30 years. At times it is very typical of lupus, at others RA, MG and now Sjogrens but still no antibodies. You may need to persevere to get your diagnosis and you may need a different rheumatologist or two before things become clear. Try not to despair, many of us have been in your situation. Xxx

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Hi Blahblahblah123,

Welcome to the LUPUS UK HealthUnlocked Community!

Extreme fatigue, skin involvement and joint/muscle aches and pains are all common symptoms associated with lupus. To find out what other symptoms are associated with lupus, you can download or request our free information pack here: lupusuk.org.uk/request-info...

We are not medically trained here therefore, we cannot comment on your blood test results.

Around 5% of people with lupus can have a ‘negative’ ANA test result.

Although dsDNA antibodies are very specific for lupus (as they are not typically seen in any other condition or in healthy population) only approximately 60% of people with SLE will test ‘positive’. Therefore if someone is positive for these antibodies, it often means they have lupus, but if they are negative it does not necessarily mean they do not have lupus. For more information, you can read our blog article on ‘getting a diagnosis of lupus’ here: lupusuk.org.uk/getting-diag...


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