Anyone taking Plaquenil and have Hashimoto's?

This is probably a strange question, but first, some history so you understand why I am asking.

In June 2014, I was diagnosed with Hypothyroidism and started on levothyroxine (brand name Tirosint). Some time later I added in Slow-Release Thyroid Extract (T3 only).

In July 2014, I was diagnosed with mild lupus (strong positive anti-dsDNA) and started on Plaquenil.

In Sept 2014, I was diagnosed with Sjogren's (strong positive SS-A(Ro) Ab ) in addition to the lupus. Meds didn't change as I was already on appropriate treatment.

Only recently, I was tested for Hashimoto's.

My results were:

TPO-Ab: 3 IU/mL (<9)

Thyroglobulin Ab: <1 IU/mL (< or = 1)

TSI: 41% baseline (<140)

So, it would appear that I am negative for Hashi's BUT I've been on Plaquenil for 9 months and never got tested prior. Could the Plaquenil cause a decrease?

For the last month I've been feeling VERY fatigued and suspected either thyroid over-medication OR under-medication. Endo said to slowly increase the Slow-release Thyroid Extract (T3) - which I did in increments over the course of two weeks - but really didn't see any change (didn't improve, didn't really get worse but maybe??). All I know is I was still VERY fatigued and unmotivated to do ANYTHING.

Having had enough, for the last two days I STOPPED taking the slow-release T3 as well as the levo and I'm feeling more normal (even hubby commented). I understand the levo change probably isn't affecting me yet as that takes time to be flushed out of your system but I do know that changes from T3 intake is seen/felt fairly quickly. So, hmmmm. Just this morning I put in a request into my endo to test TSH, FT4, FT3, RT3, Vit D, Vit B12, Folate, Iron, and Ferritin so that we can figure out what is going on.

This all just seems so strange to me. So, either I have been over-medicated, OR perhaps I never was really hypo at all OR perhaps I did/do have Hashi's and the Plaquenil is keeping it in check so I no longer need thyroid meds? Or, simply, just don't need T3?

So confused.


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