AnndexXa approved for

[Wittycjt]

Xaralto/riveroxaban and apixaban anticoagulant reversals of Xa inhibitors.... different dosages, in the USA

[Wittycjt]

True but there are some people on those meds here and they may need to know esp because they aren’t proven safe

[Tofino5]

Yes that's right. It is good to know that if it's ever needed (if I'm ever laying bleeding on the sidewalk or in a car wreck) that a reversal has been approved for use. Thanks for posting.

[KellyInTexas Administrator]

Jill Schofield does prescribe these more often than not. It will be interesting to see how the shake up in TRAPS trial will affect the use of NOACS/ DOACS here.

It has affected me already. ( although it only played a part. “ reinforced an already held stance of my Hematologist.)

I met with my Hematologist yesterday to go over my London appointments. He did not give the thumbs up on switching to enoxaparin.

1. He felt that my case of APS was too severe.

2. He felt that we could run my INR as high as 4.5-5. to accommodate dips in INR-

3. Mainly,and most importantly- warfarin is the, “tried and true staple mainstay “ when other therapies can come and go. He just does not want to do ,” trial and error” with me in particular because I need such a high INR and I did so poorly so quickly on exoxaparin last time- although he agreed it should have been every 12 hours , etc, etc.

Most important sentence- “ Tried and true thus far “... and for me personally- he was leery of the titration risks. He said my INR needs are simply too high.

Let’s see how it goes over time.

[Wittycjt in reply to KellyInTexas]

It will be interesting to see how this plays out now that she is re-arranging her office, office visits, and prescribing meds.Yes, time will tell a very big story regarding this.

[DRGPS51 in reply to Wittycjt]

Hi! Curious to know what happened with the TRAPS trial? Thanks.

[Wittycjt in reply to DRGPS51]

Riveroxaban failed big time! Google “TRAPS trial”, Cindy

[AnnNY]

Thanks, Witty. I'm sure my GP/PCP will be happy to know that there is a reversal agent, even though I don't have side effects from the Eliquis.

[Wittycjt]

I’m glad you guys appreciate the information, I thought some might. I hope you will never have to need it🧠

[KellyInTexas Administrator]

Only in catastrophic events I suppose. Otherwise it’s out of system so quickly.

[KellyInTexas Administrator]

Yes. It’s certainly a hypocrisy for sure.

But then again- you’ve hit the subject you and I share such a passion for.

[MaryF Administrator in reply to KellyInTexas]

I must say I do agree, and the patients need to be in the know and be aware of the discontinued trial. MaryF

[Wittycjt]

I must agree about the risk as my cardio was not comfortable with raising my INR from 2-3: for risk of bleed...that’s why I was so nervous on warfarin but my cardiologist would not permit enoxaparin until I spoke with hematologist and she agreed with it... then it was “okay”.

Its my understanding in the US that they will only use other NOACs if warfarin fails but who knows.... it really is very confusing 🤨 I know my docs won’t okay the NOACs