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Androgen deprivation therapy (ADT)
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Testosterone recovery after stopping ADT - 3
This plot shows the % of men who recovered their original testosterone level after stopping Lupron
ADT
, plotted versus the time (months) after stopping
ADT
, for three different durations of
ADT
(4, 6-12, or 24 months).
This plot shows the % of men who recovered their original testosterone level after stopping Lupron
ADT
, plotted versus the time (months) after stopping
ADT
, for three different durations of
ADT
(4, 6-12, or 24 months).
janebob99
in
Prostate Cancer Network
2 months ago
Testosterone Recovery after stopping ADT -2
For
ADT
of 4 months, 50% of men will fully recover their testosterone in 5 months. For
ADT
of 4 months, 50% of men will fully recover their testosterone in 24 months. Roughly speaking, on average, the T-recovery time equals the duration of
ADT
.
For
ADT
of 4 months, 50% of men will fully recover their testosterone in 5 months. For
ADT
of 4 months, 50% of men will fully recover their testosterone in 24 months. Roughly speaking, on average, the T-recovery time equals the duration of
ADT
.
janebob99
in
Prostate Cancer Network
2 months ago
Testosterone Recovery for 50% of Men
Here's an updated plot of Testosterone recovery time for 50% of men after stopping Lupron
ADT
, as a function of
ADT
duration.
Here's an updated plot of Testosterone recovery time for 50% of men after stopping Lupron
ADT
, as a function of
ADT
duration.
janebob99
in
Prostate Cancer Network
2 months ago
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ADT yes or no
My urologist has recommended
ADT
treatment followed by radiation. I am concerned about the
ADT
because of the side effects. What are the risks with radiation without
ADT
?
My urologist has recommended
ADT
treatment followed by radiation. I am concerned about the
ADT
because of the side effects. What are the risks with radiation without
ADT
?
MontanaMan
in
Advanced Prostate Cancer
3 months ago
ARASENS Darolutamide vs Placebo
The multiplier is about a factor of 2 better for Darolutamide +
ADT
+ Docetaxe, compared to Placebo +
ADT
+ Docetaxel. The Cohort was High Risk men. https://ascopubs.org/doi/10.1200/JCO.23.00041
The multiplier is about a factor of 2 better for Darolutamide +
ADT
+ Docetaxe, compared to Placebo +
ADT
+ Docetaxel. The Cohort was High Risk men. https://ascopubs.org/doi/10.1200/JCO.23.00041
janebob99
in
Advanced Prostate Cancer
2 months ago
Reason for ADT
Why is
ADT
used after SBRT? If radiation kills the cancer or makes it impossible to reproduce, then why do some doctors recommend
ADT
?
Why is
ADT
used after SBRT? If radiation kills the cancer or makes it impossible to reproduce, then why do some doctors recommend
ADT
?
Victor615
in
Prostate Cancer Network
2 months ago
Tri modality conclusion end of ADT nervous
I’m 4+3 unfavorable ..no PSMA scans available yet here…though Osaka university just started.. with over 9 months of
ADT
I’m stopping .. doctor said ok and didn’t recommend the last two months ..anyone else get nervous stoping the
ADT
? When to say it’s enough ?
I’m 4+3 unfavorable ..no PSMA scans available yet here…though Osaka university just started.. with over 9 months of
ADT
I’m stopping .. doctor said ok and didn’t recommend the last two months ..anyone else get nervous stoping the
ADT
? When to say it’s enough ?
Yokohama2023
in
Advanced Prostate Cancer
1 month ago
Sexual function
I am post
ADT
20 months! Still have very to to no seamen on ejaculation and can get erection but certainly not has hard as before
ADT
. Has anyone experienced this?
I am post
ADT
20 months! Still have very to to no seamen on ejaculation and can get erection but certainly not has hard as before
ADT
. Has anyone experienced this?
Stecruz
in
Advanced Prostate Cancer
1 month ago
Rising PSA post RP,IRT,ADT
Year post RP,IRT,
ADT
.. understand if goes to .2 new scans and possible Radiation. I surely don't like the
ADT
.. Any thoghts
Year post RP,IRT,
ADT
.. understand if goes to .2 new scans and possible Radiation. I surely don't like the
ADT
.. Any thoghts
ChristopherH
in
Advanced Prostate Cancer
2 months ago
Radiation?
Don’t know if I’ve provided enough info for this question…..but would more radiation be of any benefit over
ADT
? Any “curative” possibility given rapid response to
ADT
?
Don’t know if I’ve provided enough info for this question…..but would more radiation be of any benefit over
ADT
? Any “curative” possibility given rapid response to
ADT
?
Tommyj2
in
Advanced Prostate Cancer
3 months ago
Embark study
What I'm wondering is, I can certainly understand that adding Xtandi to the intermittent
ADT
treatment delays average time to metastasis, but in doing so, am I just borrowing from what would otherwise by my standard post-intermittent-
ADT
treatment, and making that post treatment less potent, so that
What I'm wondering is, I can certainly understand that adding Xtandi to the intermittent
ADT
treatment delays average time to metastasis, but in doing so, am I just borrowing from what would otherwise by my standard post-intermittent-
ADT
treatment, and making that post treatment less potent, so that
billfenley2
in
Advanced Prostate Cancer
2 days ago
Estrogen ADT vs Lupron ADT
Here's a chart showing % of men who have a given condition, comparing Estrogen
ADT
versus Lupron
ADT
. There's big reduction in hot flashes, and improvements in libido, when taking supplemental Estrogen. Estrogen increases gynecomastia (enlarged breasts), however. Bob
Here's a chart showing % of men who have a given condition, comparing Estrogen
ADT
versus Lupron
ADT
. There's big reduction in hot flashes, and improvements in libido, when taking supplemental Estrogen. Estrogen increases gynecomastia (enlarged breasts), however. Bob
janebob99
in
Prostate Cancer Network
2 months ago
Decipher question
But Decipher, which focuses on various statistics, doesn't say what the improvement would be with
ADT
. Does my chance of meta go down significantly by adding
ADT
?
But Decipher, which focuses on various statistics, doesn't say what the improvement would be with
ADT
. Does my chance of meta go down significantly by adding
ADT
?
gualala
in
Prostate Cancer Network
2 months ago
No Osteoporosis with Estrogen Patch Therapy
These plots compare results from the Phase-II randomized trial (PATCH) comparing estrogen patch therapy to Lupron
ADT
. These plots show that Lupron
ADT
causes bone loss, while estrogen patch therapy has either no bone loss or increased bone mineral density (BMD) over time. Bob
These plots compare results from the Phase-II randomized trial (PATCH) comparing estrogen patch therapy to Lupron
ADT
. These plots show that Lupron
ADT
causes bone loss, while estrogen patch therapy has either no bone loss or increased bone mineral density (BMD) over time. Bob
janebob99
in
Prostate Cancer Network
2 months ago
New data about ARASENS trial: it seems to work well after longer observation
Post-Hoc Analysis of ARASENS Reinforces Use of Darolutamide/
ADT
/Docetaxel Combo as SOC in mHSPC https://www.onclive.com/view/post-hoc-analysis-of-arasens-reinforces-use-of-darolutamide-
adt
-docetaxel-combo-as-soc-in-mhspc
Post-Hoc Analysis of ARASENS Reinforces Use of Darolutamide/
ADT
/Docetaxel Combo as SOC in mHSPC https://www.onclive.com/view/post-hoc-analysis-of-arasens-reinforces-use-of-darolutamide-
adt
-docetaxel-combo-as-soc-in-mhspc
Maxone73
in
Advanced Prostate Cancer
3 months ago
Silly Questions??
1) Why do some advanced prostate cancer patients get offered "vacations", from
ADT
and others don't? 2) Why do some advanced prostate cancer patients have NO Chemo, and go directly to
ADT
+ Abiraterone+Prednisone, while others begin treatment with chemo and radiation?
1) Why do some advanced prostate cancer patients get offered "vacations", from
ADT
and others don't? 2) Why do some advanced prostate cancer patients have NO Chemo, and go directly to
ADT
+ Abiraterone+Prednisone, while others begin treatment with chemo and radiation?
TommyCarz2
in
Advanced Prostate Cancer
2 months ago
On treating micro-metastatic disease
Thereafter just monitor the PSA for any rise, and use PSMA PET scan to locate any cancer and to radiate whatever spots of cancer that are found.This May I will reach the one year mark of my
ADT
and seriously considering stopping the
ADT
because of the side effects... fatigue, muscle loss, forgetfulness
Thereafter just monitor the PSA for any rise, and use PSMA PET scan to locate any cancer and to radiate whatever spots of cancer that are found.This May I will reach the one year mark of my
ADT
and seriously considering stopping the
ADT
because of the side effects... fatigue, muscle loss, forgetfulness
John347
in
Advanced Prostate Cancer
2 months ago
Low testosterone is associated with extremely poor survival metrics, post-ADT.
The cohort is 58 men with unfavorable intermediate risk who underwent RT and 6-months of
ADT
.
The cohort is 58 men with unfavorable intermediate risk who underwent RT and 6-months of
ADT
.
janebob99
in
Prostate Cancer Network
1 month ago
ADT or Orchiectomy & side effects
I have been on
ADT
for 18 months the Side effects are a little better but still horrible!! Q) If i have a Orchiectomy, can I stop the
ADT
therapy altogether? Currently on Xtandi and Orgovox. thanks
I have been on
ADT
for 18 months the Side effects are a little better but still horrible!! Q) If i have a Orchiectomy, can I stop the
ADT
therapy altogether? Currently on Xtandi and Orgovox. thanks
lookout4
in
Advanced Prostate Cancer
3 months ago
ADT & Mets
Are we wasting time going onto
ADT
if that treatment is mainly for contained PCa? Or will the
ADT
put a lid on the Mets wherever they are in our body? Keep in mind that we are totally oblivious of having Mets at the time of starting
ADT
.
Are we wasting time going onto
ADT
if that treatment is mainly for contained PCa? Or will the
ADT
put a lid on the Mets wherever they are in our body? Keep in mind that we are totally oblivious of having Mets at the time of starting
ADT
.
CJ1958
in
Advanced Prostate Cancer
3 months ago
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