Fungal Infection Trust

Persistent fungal issues: really CAUSED a defective immune response . . . due to 'L-form' bacteria ? ? ?

If the above proposition is true, trying to eradicate the fungal infection ( - e.g. PERSISTENT athlete's foot) directly will be FUTILE ! ( - this has been PRECISELY my experience over several decades now !).

Information about L-form bacteria disrupting the immune response by causing a "vit D dysfunction" ( - and such a "dysfunction" being SEEN in those with many fungal conditions ! ! !) can be found at:

I bet** YOU a £1 your GP or specialist knows NOTHING (or nothing much) about this ! ! ! Do bring it to their attention, . . . . . . . after perhaps getting to grips with the basics yourself.

[ ** - genuine bet, but T&Cs apply ! ;~))x]

A gentler introduction can be found in an online article by Meg Mangin. To find this, search for: "Fearless Parent November 2014 Vitamin D".

PLEASE DO consider this as ONE possible mechanism for the actual CAUSE of your on-going fungal issues. There DOES seem to be MUCH to this, . . . . . in my view !

ANY & all feedback on this GRATEFULLY appreciated - especially if you know of a consultant in the UK USING this protocol to treat those with fungal issues.

Take care,




4 Replies

L-forms have been extensively researched as they are a source of antibiotic resistance to several common antibiotics. Their wider implications are now an interesting subject - in fact we are seeing this in more than one area of illness were we are seeing microbes persisting in our bodies were before we assumed they had all gone. Perhaps these are challenging old ideas and it takes time for them to become generally accepted. Perhaps as antibiotic resistance becomes more important as we run out of effective antibiotics this is stimulating more research.

A GP might not need to know about this in any detail. All they might need to know is if an infection fails to clear up then change the type of antibiotic and monitor the infection.

In terms of vitamin D we have looked at this and so far found little correlation between having aspergillosis and the levels of vitamin D in the blood of our patients, so at the moment we assume it is not vitally important. We do however advise supplements if levels are low.


Thanks for this informative feedback, GA !

a) L-forms ( - & similar bacteria?) have been extensively researched . . . . ( - glad to hear it !), . . . . . . . is this specifically concerning fungal infections, or more generally, I wonder ?

b) did not realise THESE were causing concern for antibiotic resistance,

c) I do know our CMO is particularly concerned about antibiotic resistance ( - given her background in medicine, I seem to recall),

d) I have no reasons to believe either that GPs concern themselves with type of infective agent ( - I certainly get the feeling they don't know about these, as you suggest) . . . . . I remain unsure ( - at present) whether the 'regular' antibiotics touch or are effective at all against this class of ( - intracellular) bacteria, usually not found in the blood and difficult to culture in the lab; I suspected they are not !

e) . . . . if, 'levels of Vitamin D' above refers to the normal blood 25(OH)D or calcidiol test, the opinion is they are/can be low in a RANGE in chronic illnesses . . . . . . . but the cause and effect may not be as assumed/presumed : that its the low level of calcidiol maintaining the illness, . . . . . rather than the other way around.

f) HERE the opinion cited puts forward the clear idea, that IN THE "vit D" dysregulated state, there TEND to be relatively HIGHER levels of the activated "vit D" molecule, the calcitriol relative to the stable calcidiol blood level. The advise to supplement to ALL with a particular calcidiol ( - or 25(OH)D) level, WITHOUT qualification is said to be PROBLEMATIC - and from the reasoning given, I can see why.

I'd be interested to see other, independent findings of both the calcidiol AND calcitriol levels ( - taken from the same blood samples) in those with persistent fungal infection issues . . . . . and how these compare to the values of the same in those (seemingly) unaffected by fungal or any other chronic health issue - this would be interesting and HELPFUL. Do please let me know if you've come across this.

Take care.


Several of our commonly used antibiotics attack the bacterial cell wall. L-form bacteria have no cell wall, several types of bacteria seem to be able to switch to L-form. Therefore one way to survive attack from some antibiotics is to switch to L-form - though few survive when they do as living without a cell wall isn't easy!

Low vitD levels do correlate with TB

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Thanks for the link to this paper, GA - it lists a host of UK academics/clinicians who will have knowledge of "vit D" biochemistry and illness/inflammation. I hope I will get somewhere sending appropriate enquiries to them !

Sadly ( - on first inspection) it does not appear that they have measured the important calcitriol metabolite . . . . . . . . . which could be an important oversight ? ? ?

Cheers !


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