My wife was 1st diagnosed with NSCLC stage 3B April 2016. She had radiation and Carboplatin treatments and was given NED diagnosis Nov 2016. PET scan in May 2017 showed cancer was back and metastatic to bone. She has had 6 rounds of Keytruda and side effects have been joint pain,mild stomach issues and extreme exhaustion. She decided to get a 2nd opinion and visited MD Anderson this week and her Medical Team there has recommended Gene Targeted Therapy because she has the EFGR. Has anyone had treatments with Gene Targeted Therapy? Thank you all we have learned so much from this group.