Published today in the journal Oncotarget, this genome wide association study quickly replicated 21 genetic variants associated with melanoma that were identified from seven other studies.
In addition to replicating those variants, the study found one novel variant near a gene region known as BASP1 which could be protective against melanoma. The researchers found that in individuals with this form of cancer,
The expression of BASP1 was suppressed, conferring an almost two-fold increased risk.
This implicates a potential tumor-suppressive role for BASP1 in melanoma,” the researchers said.
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