At first, it will sound as irrelevant to PCa, but my belief is that the medical community should learn from other industries when prescribing dosages. In a nut shell, more can be disastrous. Today, Sunday morning at 10 AM, as you can see from the attached graph, the grid voltage went crazy. Grid voltage (nominal value: 230V +10%/-15%) went as down as to 136V on the graphed phase, causing a led lamp to dim-off completely, and up to ~270V on the other 2 phases of the 3 phase low tension distribution system. You may want to how/why this happened. The answer is easy: Sunday morning the grid power consumption was at its lows, the sky was clear and there was also a light breeze of air. The photovoltaic and wind production plants were pumping energy on the grid at their fullest, while the overall consumption was low. The perfect scenario for a black out! If you look at the graph closer, you will spot out that stability returned twice after deep notches. Grid protection was probably auto-activated to shed off photovoltaic and/or wind power plants, or compensate for the unused real/imaginary power in any other way.
Now you may understand my Bicalutamide maneuvers. More, than needed, Bicalutamide may promote castrate resistance . Well, this is relevant to PCa. No?
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Justfor_
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As I understand it, you are monitoring to take the min amount of Bicalutamide to keep psa below a certain level. Makes a lot of sense, especially if you think that the total amount of Bicalutamide consumed to date is related to the development of castrate resistance, is that the theory? If I decide to avoid SRT I may consider a similar approach with the E2 gel. It also has always seemed odd to me that medical dosage is not usually related to body mass. I weigh 105kg+ but am not really that overweight for build and height, but i find myself taking the same dosage of things that an adult nearly half my weight would take ... which seems odd!
Thanks for your kind wishes. The level is not the primary target. The stability is. I have been using a lab that reports PSA to the second decimal place. The analyzer they use is a Cobas 8000 e801-1, e801-2, by Roche, advertised to have a Limit of Detection (LoD) of 0.010 and a Limit of Quantification (LoQ) of 0.014. I got 3 consecutive monthly tests of <0.01. Most people here would go around and brag about it. I was very concerned because "undetectable" is synonymous to "I have no idea were I am at". I switched to a different lab that reports to the third decimal place and uses an ALINITY ΜΤ-24-01 by ABBOTT with a LoD of 0.003. Now, I know were I am at and can adjust dosing for equilibrium. That is, for every hormone sensitive newborn cell, one existing should be killed or put to sleep, otherwise the hormone indifferent will fill the void like gases fill any vacuum. I don't believe that this mild pressure on the hormone sensitive cells will 100% block the advent of their dreaded cousins, but at least I find it very silly to throw welcome parties in their honour.
Justfor_. Now that is a lovely metaphor, “I find it very silly to throw welcome parties in their honour.” Explained and spoken not like any SOC MO whom I’ve ever encountered.
Justfor_, You and ragnar just made my day! As the trademarked saying at one of the CLL patient support sites, CLL Society, reads, "Smart Patients Get Smart Care™".
Some big brains thinking large and finding those connecting patterns using lots of "Range" to do so. Thanks for the insights.
There is a lot kitchen hardware revolving around PCa. I already knew about the kitchen sink. New entry to me the "range" cooker. I will try to come up with something new pertinent to a toaster, a blender, or some other utensil . (just pulling your leg cujoe, filling in for my compatriot J-O-H-N).
You could have signed it as j-o-h-n and I might not have noticed the actual source - and, no doubt, j-o-h-n would have approved of the context of and for the humor. Have a good weekend!
You know that graph is something that might just be relevant to PCa because we get radiation. And even the best clinics are probably not paying much attention to voltages since their physical plant guys do that. I and a friend in Florida both had "simple" radiation and came away with severe radiation burns. My RO (radiation oncologist) is completely baffled and fears having to irradiate me again. However voltage spikes would explain a lot.
And while they're all in CYA mode, no one has done anything for me: no ENT to check out damage to my throat, no neurologist to figure out what's gone wrong in my cervical spine, nope nothing at all. I am struggling along as well as I can and hope my new PCP in July will be able to help as she is outside the university where they are treating my cancer.
Standard radiation can burn the crap outta surrounding organs. This is why PBT work better for guys who can get Medicare or their health insurer to pay for the proton beam treatment. The proponents of the old radiation methods will come charging out of the sidelines screaming the usual propaganda against PBT, but o matter the old arguments, it is far less toxic to surrounding tissue. I t stops and does not flow through the body and out your back. They use it over in Jacksonville, FL at the UF PBT facility, but you would find it difficult to get a referral from the Gainesville radiation department across the state.
I’m so sorry that you’ve suffering with the ADT SEs of advanced PCa care. You can explore BAT, and some of the radioligand innovations that are being rolled out ever so slowly. Good luck.
I tries to , but .... " We're sorry, the page you've requested does not exist at this address. The page you are looking for might have been removed, changed, or is temporarily unavailable. " ???
" Despite the significant relative decrease in second cancer risk in PBRT-treated patients, the absolute benefit was small because of the rarity of second cancers. In older patients, the clinical impact of this benefit is uncertain because of the low absolute risk of second cancer development and the presence of competing risks for mortality. Conversely, those more likely to benefit from PBRT are patients who face a higher absolute lifetime risk of second cancer. Pediatric and young adult patients are at increased risk because of their potential for long life expectancy and heightened susceptibility to treatment-induced malignancies.16 "
"In a span of five years post-radiation, only 1 in 333 patients developed second primary cancer, according to the study. Fifteen to 20 years after treatment, that number rose to 40."
For a medical practitioner 40/333=12% is a "small" percentage. For an engineer, just unthinkable. Imagine 12 out of 100 bridges collapsing after 15-20 years of use. Average of 2.9 hours per day without electricity. War zone conditions in my book.
yes, different worlds. So, does that mean that in 5 years, a similar group of non-radiated developed no cancers? I would doubt that. Same with the 15-20 year results, as we know that cancer is more common than any other " disease" other than cardiovascular . In other words, were the 40 cancers attributed to long-term impact of radiation? I don't think so, but maybe I'm wrong?
Thanks, Ragnar2020. I will keep this in mind for when I next need radiation as I'm at that phase of the disease: no real promising treatments, just keep me comfortable with irradiating painful areas and high doses of narcotics -- both of which I'm putting off as long as possible (I don't react "normally" to narcotics, either).
Oh, and I'm in Rochester, NY, now. Left Florida for a more friendly state with more robust assistance programs.
Getting irradiated is not a stroll in the park as some people think here. During the time that there was a Radio officer aboard every merchant ship, they had to dwell within the radio room (at bridge level) where the short wave communication equipment was located. After a multi-year service there where enough "unexplainable" illnesses appearing to them, that made all the newly build ships to have the transmitter placed in an adjacent, but separate, room to the radioman's dwelling. And mind you that the body penetration of shortwaves is nothing compared to that of microwaves employed in RT. That is the reason I try to push down the road any sRT.
Not necessarily for the usual house loads. For industrial loads, overload/over-under voltage protection will get engaged, thus switching them off, thing that will create a vicious cycle that ultimately will lead to a black-out.
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