A Reason why Checkpoint Inhibitors may not be effective has been found...

[NPfisherman]

The discovery of Checkpoint Inhibitors was hailed as a possible cure for cancer and for some, like ex-President Jimmy Carter, they have been quite successful. New research at the Technical University of Munich found that inactivation of a protein receptor led to decreased responsiveness to Checkpoint Inhibitors...

RIG-I is a receptor protein that is known to play a role in the body's defense against viruses. Heidegger and a team headed by his colleague Dr. Hendrik Poeck have now discovered that RIG-I also plays a key role in cancer control.

short version:

sciencedaily.com/releases/2...

Article:

immunology.sciencemag.org/c...

Fortunately, a drug already exists that activates RIG-I, and it is already undergoing initial tests in clinical trials with humans...

The Science is Coming....

Don Pescado

[cujoe]

Don Pescado - Many thanks for your continued reporting on the science of cancer/PCa. Be Well - cujoe

[NPfisherman in reply to cujoe]

Following the Science is my passion... posting it here helps others know that...

The Science is Coming !!!

Looking for some major drugs to move on to Phase 3 soon...

Don Pescado

[Sunlight12]

I love your posts, Fish! It's so encouraging to read about all these new possibilities on the horizon

-Sunlight

[NPfisherman in reply to Sunlight12]

Thank you Sunlight12....

The Science is Coming fast, but I want it to be faster...

There are multiple promising CAR-T or "engineered" CAR-T studies in progress and will be in clinical trials--vaccine trials. Advaxis has a vaccine through Phase 2...

Several new bromodomain inhibitors which can block BRD4 and p300 which drive HULLK in prostate cancer....

newsroom.uvahealth.com/2019...

These new bromodomain inhibitors will be add ons to Zytiga, Xtandi, Erleada for those that develop resistance.. Drugs to add macrophages to the fight in preclinical and Phase1/2...

SM-88, VERU-111, ARV-110, and many other new drugs...It just takes time, and sadly, many do not have that time... I stick with my prediction of chronic disease state in 5 years and a cure in about 15 years...

Have a great day...

Don Pescado

[Sunlight12 in reply to NPfisherman]

I agree - I too want it to be faster!

I've read about about the CAR-T and that process looks very exciting. As does the new process you just posted about that's coming out of Yale. I will do some reading on the others this weekend!

May your prediction be right at worst ...and too generous at best!

-Sunlight

[NPfisherman in reply to Sunlight12]

Another CAR-T for the road...I believe it is 3 or more already....

sciencedaily.com/releases/2...

The Israelites... strike again... let's not forget..."nanoghosts"...perfect at Halloween time...

worldisraelnews.com/israeli...

Have a great day...

Don Pescado

[j-o-h-n in reply to NPfisherman]

Great post to a Great guy from a Great guy.👀

W - E - L - C - O - M - E.....B - A - C - K....... Patrón

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 10/17/2019 4:47 PM DST

[Sunlight12 in reply to NPfisherman]

Wonder if I could get my Dad to dress as a Nanoghost for Halloween

[NPfisherman in reply to Sunlight12]

I do not even know what a "nanoghost" looks like but I am intrigued... The Science is advancing incredibly with CRISPR able to cut DNA and they are looking at adding DNA to make cells normal--convert cancer cells...just wild... I watch with wonder and HOPE !!!

Hoping for some "treats" for all of us soon...

Don Pescado

[Sunlight12 in reply to NPfisherman]

I say we all go trick-or-treating to the nearest big teaching hospitals and tell them we're here for the PCa-cure treats! ...who knows, maybe they'll dispense some

[tango65]

Very interesting. SLR 14 seems to activate the RIG-1 receptors.

jem.rupress.org/content/ear...

Thanks for posting this information.

[NPfisherman in reply to tango65]

tango65,

Thank you for your reply...interesting reading... I posted on CpG on the other forum 9 months ago... this article

sciencedaily.com/releases/2...

and then followed up with an article about a CLEVER-1 antibody therapy--headed to Phase 1--

clincancerres.aacrjournals....

I believe by activating macrophages and getting memory T cell immunity --CD4 or CD8 memory cells that can fight on and on when exposed to cancer cells, even post re-inoculation, will be the answer to our issue...

It is why I got excited with the CAR-T infusion with vaccine chaser that MIT did a few months ago.. A 60% cure rate in mice and continued cure despite re-inoculation with cancer cells...

The Science is Coming and it gives me HOPE ...

Don Pescado