Hello can someone please tell me what... - Fertility Network UK

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Hello can someone please tell me what is involved in a frozen embryo transfer?

Katrina13 profile image
7 Replies

I am trying to think ahead, having just failed our first IVF cycle. We have 6 blastocysts of various qualities frozen. What I would like to know is:

1. How long before you can try a FET?

2. What is the regime, injections?

3. How long does it all take?

Many thanks ladies xx

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Katrina13
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jenny34 profile image
jenny34

Hi, I've just replied to your earlier post too xxx

I am in similar position to you I think. BFP on 1st fresh cycle within last 2 weeks. We have 5 frosties. I have review with consultant tomorrow to look at next steps, so will know more then.

From what i've read, Care seem to want you to have this period (with BFN), then another 'normal' period, then you can look at having a fet. Will share any more news with you following review tomorrow. I've been told by many people that nowadays there is not much difference between success rates of fresh or frozen cycles. Was hoping to be able to have a frostie put back with no drugs, but apparently the success rate is better with medicated frozen cycles.

Either way, from what I've been told, a frozen cycle is no-where near as draining, invasive and stressful, as not so many drugs. I think drugs-wise it depends on you and your individual circumstances, but the main thing is to thicken the womb lining to ensure emby sticks.

Are you with care?

hope this helps and sending lots of love xxx

DianeArnold profile image
DianeArnoldPartnerNurseFertility Network UK

Hi maccerpops. Obviously, it will at the discretion of your clinic when you can try a FET, but can be as early as 2 months after a failed fresh cycle. There are several ways to do this. Your consultant will decide what would be the best way for you. I’ve listed the current methods and hope it helps to explain it all for you. Diane

Natural Cycle

The natural cycle method involves telephoning your patient coordinator on the first working day after Day 1 of your period. He/she will then advise you when to commence the Clearplan Urine Kit or daily blood tests to detect ovulation. You will have an ultrasound to confirm the development of your follicles. The transfer of the embryos will be timed for two or three days after ovulation, depending on the age and development of your frozen embryos. On average 2 out of 3 embryos successfully thaw. On the day of transfer you then phone the clinic to check if the embryo/s have survived the thawing process before being admitted to hospital. The embryos will be transferred to the uterus in the same way as a fresh transfer. You will usually be required to use progesterone pessaries/cream after your embryo transfer. DO NOT stop the medication unless instructed by the clinic. A pregnancy test is done approximately 14 days after transfer, as usual. It is important that this test is performed even if you experience bleeding suggestive of a period.

Clomiphene Cycle

This type of cycle is the same as the Natural Cycle above but with the addition of Clomiphene as prescribed (usually Day 2 to Day 6).

Hormone Replacement Therapy (HRT) Cycle

You will be asked to phone your clinic prior to your expected period when he/she will explain the proposed treatment regime. You will be required to use the Oral Contraceptive Pill and Buserelin or Lupron followed by a blood test similar to the Down Regulation phase of a Stimulated Cycle. If the result of the blood test is satisfactory, you will commence taking oestrogen tablets morning and night (Day 1 of cycle).

You will have two ultrasound appointments between 8 and 14 days after commencing the oestrogen tablets. If the ultrasound result shows that the lining of the uterus is adequately prepared you will be advised to stop the Buserelin or Lupron, continue oestrogen and commence Progesterone and any other medications prescribed. Your embryo transfer will then take place in two or three days' time. Continue to take all medications as instructed until the result of your pregnancy test is known. On the day of transfer contact the clinic an hour before the procedure, to confirm that your embryo(s) have survived the thawing process. The embryos will be transferred in the same way as a fresh embryo transfer. A pregnancy test will be performed 14 days after transfer, just the same. (The medications prescribed by your Fertility Specialist may prevent a period even if you are not pregnant.) If the pregnancy test is positive, the medications will need to be continued until your Fertility Specialist advises otherwise. If the result is negative, the medications can stop. It is important that this test is performed even if you experience bleeding suggestive of a period, as with the other regimes.

Katrina13 profile image
Katrina13 in reply to DianeArnold

Thank you, very helpful.

jenny34 profile image
jenny34

Thanks Diane for the info. Hi Maccerpops, I just wanted to update you following my review yesterday.

Consultant wants me to do a natural cycle - pretty much as Diane has stated above. The only drugs I will have are the pessaries. He said that Care always recommend a natural cycle if you are under 38 and your cycle is regular.

I asked about endo scratch and he said that there is no test for whether you need this or not, but it is something they would suggest if I had had several miscarriages. He said I can have embryo glue if I want (£95 extra) but he does not believe it makes a difference. He said that as this is only our 2nd attempt after 1 failed fresh cycle, we should just 'go with it' and try to relax, which I do agree with.

In terms of timescales, I was surprised when he said we could start on my next period/cycle. I had been told by the nurse when I called to tell them I had BFN that I would need to have a 'normal' cycle following the period from the BFN. But consultant said I can try again next period.

We are in 2 minds about this. Part of me thinks I should give myself more time to get over the fresh cycle, physically. But of course the other part of me wants to just get on with it!

Hope this helps. Any thoughts on whether I should wait a month or just go for it would be great!

xxx

Katrina13 profile image
Katrina13 in reply to jenny34

I dunno about you but I need a break! Planning a holiday in May :)

jenny34 profile image
jenny34

Up early like me! :-) I know, I feel that too, but I worry about getting older and that decreasing my chances! :-S xxx

Katrina13 profile image
Katrina13 in reply to jenny34

A month or two won't make a whole lot of difference!

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