Has anyone had a problem with the use of amlodipine? I take Keppra (2500 daily) and Lamotrogene (150mg daily) and also take amlostin 5mg daily, ramipril 1.25mg daily for blood pressure control plus artorvastatin 20mg daily cholesterol control. There appears to be a shortage of amlostin (5mg daily) and was issued a generic amlodipine 5mg medication. Within 4hrs of taking the first tablet of this generic medication I 'd had 2 seizures (partial complex) and 1 momentary blackout. I've had no more blackouts since and the seizures, partial complex, (which reached about 5 on first day) have now, a full week later, reduced to 2 - 3 per 24hrs (my usual is 1 - 2 per 24hrs). The only difference I could find on the drug packets was that Amlostin is an amlodipine maleate while the generic was amlodipine besilate and the amlodipine was the only change in any of my medications. Luckily my pharmacy (Lloyds) managed to locate a months supply of the previously used Amlostin and now thing are slowly beginning to settle down again and my medical practice has made a note that all future amlodipine must be maleate. There were other side effect also felt, palpitations, dizziness, vertigo and nausea. Does anyone know if this is a known problem or am I just an oddball? I am obviously concerned about the possibility of future problems when the current tablet end if there are no longer Amlostin available and what the likely hood of a reaction to a generic maleate version.
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