Understanding the role of kidneys in blood glucose regulation . A short summary .

[patliputra]

ncbi.nlm.nih.gov

Ajamc.com

The regulation of glucose production uptake reabsorption and elimination is handled by several organs notably, the Pancreas and Liver.While traditionally not discussed is kidneys contribution to maintaining glucose homeostasis .It is multifaceted and include such functions as gluconeogenesis and glucose reabsorption . Latter being mediated by active ( sglt) and passive (glut) transporters.

Under normal circumstances , glucose filtered by glomeruli is completely reabsorbed, but in condition of hyperglycaemia or reduced absorptive capacity, glucosuria may occur. In hyperglycaemia , the kidneys may play an exacerbating role by reabsorbing excess glucose, ultimately contributing to chronic hyperglycaemia and subsequently Beta cell failure,insulin resistance and decreased glucose uptake. Hyperglycaemia in turn detrimentally affects the kidneys by damaging glomeruli ultimately causing microalbuminuria and nephropathy.

Knowledge of kidneys role in glucose homeostasis and the effect of glucose dysregulation on the kidneys is critical to optimal management of t2dm and prevention of renal complications.

[suramo Star]

patliputra

This is a very weird theory. I have discussed this topic in "ominous octate " post by drdharmendrapanchal. Sorry i couldn't find it. Somebody please help.

1) kidneys are victims and not the cause.

2) normally K absorb 100% glucose from the filtrate from glomeruli. However when bs levels go beyond certain levels it fails to absorb complete load of glucose . This is an endeavor by the nature to keep bs within a limit.

3) "In hyperglycaemia , the kidneys may play an exacerbating role by reabsorbing excess glucose, ultimately contributing to chronic hyperglycaemia and subsequently Beta cell failure,insulin resistance " 🐒🐒🐒.

When K absorb 100% glucose there is no Q of K absorbing excessive glucose. Hyperglycemia occurs due to ir and HG causes K to leak glucose. No organ can act in a way that will damage itself. Can't go in a suicidal mode. No organ.

Sglut2 inhibitors are illogical and potentially harmful.

[cure Administrator in reply to suramo]

healthunlocked.com/diabetes.....

here it is bhai suramo