HOW IS DIABETES caused A technical view

HOW IS DIABETES caused A technical view

I had posted earlier last week on the topicLipodystrophy and leptin harmone treatment for A small group of thin patients who develop disorders typically tied to obesity and Diabetes2 (see linkbelow)

Obesity is not widely considered a protective mechanism. Quite the opposite is true.. It’s usually considered one of the causal factors of the metabolic syndrome and insulin resistance. Obesity is a marker of disease, but ultimately it serves to protect the body from the effects of hyperinsulinemia.

Claire Johnson a patient with a rare case of lipodystrophy, a genetic disorder characterized by the lack of fat. She was skinny but always ravenously hungry and could never get fat, because she lacked fat cells.

She was finally diagnosed in 1996 with lipodystrophy by Dr. Simeon Taylor, who was chief of diabetes at the National Institute of Diabetes, Digestive and Kidney Diseases. The above case signifies thatwe need to understand the new paradigm of insulin resistance how insulin resistance, obesity, fatty liver, and fatty pancreas are actually all the different forms of protection our body uses.

The basic problem is hyper-insulinemia. There are many possible causes of too-much-insulin, but one of the major ones is excessive dietary intake of food particularly sugar. However, this is not the only cause.

Insulin has several roles. One is to allow glucose into cells. Another is to stop glucose production and fat burning in the liver (gluconeogenesis). After this stops, then it stores glycogen in the liver and turns excessive carbohydrates and protein into fat via de novo lipogenesis. Insulin is basically a hormone to signal the body to store some of the incoming food energy, either as glycogen or fat.

When insulin falls, during fasting, the reverse happens. The body releases some of this stored food energy to power the body. If feeding and fasting are relatively balanced, then it all works as planned.

However, if insulin becomes excessive, then the body is always trying to store glycogen and fat. Since there’s not much room for glycogen, it produces fat. (Note – this is normal. This process reverses during fasting) The liver exports this fat out as triglycerides along with very low density lipoprotein (VLDL) to other organs but particularly to fat cells called adipocytes

which are specialized cells to store fat. Having more fat cells is not particularly dangerous. The fat cell is designed to hold fat, so you don’t get sick from it. Obesity itself is not the cause of the problem. The critical problem occurs when you get fat where it’s not supposed to be.

It’s usually first noticed in the liver. Fat is not supposed to be stored in the liver. But under conditions of hyperinsulinemia and excessive carbohydrates, it can.. Glucose get turned into fat and too much of it ends up in the liver instead of the fat cells. The fat cells (adipocytes) are trying to protect the body by holding the fat in a safe place. Fat inside the fat cell is OK. Fat inside the liver is not.

The fat cells actually have a secondary protective mechanism. The expansion of the fat cells encourages the release of leptin, which will cause us to stop eating. However, over time chronic excessive release of leptin will create leptin resistance, which is what we find in common obesity.

So the liver tries really, hard not to get anymore fat. But insulin is pushing really hard to shove more fat into the liver. In Claire Johnson’s case, there are no adipocytes to hold this excess fat so it must remain in the liver and other organs. Develop insulin resistance of course! . So the glucose piles up outside in the blood. The insulin resistance is not a bad thing, it’s a protective mechanism. to resist insulin.

the liver in trying to pump out as much of the fat as it can. It’s pumping out triglycerides d triglyceride levels go up (a classic sign of metabolic syndrome). It’s trying to relieve the fat-engorged liver by exporting it out. So muscles get fat, and you get fatty muscle.

The pancreas also gets some fat and you get fatty pancreas. As the pancreas becomes distended with fat, it produces less insulin. because it’s trying to protect the body from the effects of too much insulin! Both the fatty liver creating insulin resistance and fatty pancreas, creating lowering insulin levels results in the same thing. Increase glucose in the blood, but organ protection against this excessive insulin. This high blood glucose causes the symptoms of diabetes – excessive thirst, excessive urination and loss of weight. The high blood glucose exceeds the renal threshold of glucose.

20 Replies

  • Read the article. Appeared on Fung's blog amongst others (Diet Doctor). Very interesting to seekers of deeper knowledge but Claire Johnson is a rare anomaly.

    For anyone else wanting a simple answer applicable to 99.9% of T2's - it's overconsumption of refined carbohydrate over a very long time! If that's the cause, then the answer is...

  • Slowly but surely the world will come to recognize this.. MikePollard

  • Mike

    sorry. I beg to differ. Yes. Refined carbohydrates are not good and must be avoided but that as the cause in 99.9 t2 is too far a thinking.

  • Type 2 diabetes is on the rise worldwide. The International Diabetes Federation (IDF) reports that as of 2013 there were more than 387 million people living with diabetes. The World Health Organization (WHO) estimates that 90 percent of people around the world who suffer from diabetes suffer from type 2 diabetes.

    Now 90% of 387 million is 348.3 million suffering T2. Perhaps you could give me your estimate of the cause of the condition OUTSIDE of excess carbohydrate consumption?

  • Mike

    1) if excessive carb consumption is the cause stopping carb diet should cure the disease. But that doesn't happen.

    2) worldwide there is increased incidences of hypothyroidism, impotence, infertility and so many other medical conditions.

    Actually our genes are weakening. Also the number of active genes are reducing in number.

    As far as D is concerned the primary cause is genetic. All other factors like diet, stress, life style etc are precipitating factors.

  • suramo if it is genetic how it gets reversed in some people ?

  • Diabetes in all the cases is not due to genetic factor . Where the root cause is genetic predisposition , mostly in type i ,it is not reversible. But type 2 is due to faulty life style which is reversible with changes in diet , physical activity , stress ,sleep , rest weight reduction and with the help of some herbs like turmeric , Azaridicta indica , harithaki ,ashwagandha gymnema , Syzyzeum jambolinum and others . All herbs do not give same results in all people .It depends on individual constitution .

  • Excess carbs should not be taken . But it does not warrant excess fats either . Any excess is harmful .Depending upon the body needs , physical work and activity ,full , whole some , balanced , diet should be taken .If possible butter milk made by adding 4 cups of water to one cup of curds from which cream is taken away , can be taken to avoid hunger pangs .To this a tea spoon of jeera can be added which is fried in a pinch of ghee . It is very helpful in avoiding the problem of constipation also .Actually more vegetables are recommended for avoiding constipation also . along with other benefits of vitamins and minerals. Thin butter milk gives feeling of fullness and answers the problem of constipation.

  • Bhaswathy.

    You may have different opinion on fats but for sure you can't take excess carbs.

  • I said reduced in take of food . Instead of going for 2500 calories a diabetic can take 1800 calories. The reduction of 700 calories reflects in the lesser intake of carbs.The ratios remain same .I mean ratio of carbs , proteins and fats .The point of contention here is as to how the body gets energy with lower levels of intake . But body has a beautiful mechanism of getting adjusted to the changes .Now that physical activity is getting reduced day by day ,the need for extra calories also . is not warranted.But when that extra need is filled by fats , the calories remain same . Only the composition is getting changed .Here we have to remember one thing . The contents and composition of fats are different from those of carbs .Carbs from whole grains , fruits , sweet potatoes etc have got better nutritional values .They come from first source where as from fats are from secondary source .Any way you are entitled to have your own views . There is no need to enter in to dispute over this . But strangely mine is branded as opinion where as yours is considered as science . A real scientific bent of mind never accepts that theory of some stalwarts here .Once again I want to re -iterate that there is no need to walk miles and miles, do jogging ,or any strenuous physical exercises with the adoption of low calorie in take .One can eat everything but in reduced quantity .

  • bhasathy are you saying carb to be taken less and fat may not increased. So only protein may be taken

    You may understand excess of protein is causes HBP and kidney problems also ? protein generally required for0.8to1gm per kg of the person But for not doing heavy work and doing table work computer work persons should be taken 0.5 gm/ kg of his wt.

    O K Please share how vegetarians to be followed the diet to maintain normal level blood sugar Please share detail of diet plan

    totally your comment may seemsgood but to clarify the diet details Thanking You for early respond.

  • no , what I say is whether it is 1500 calories or 2000 calories , or more the ratio of carbs , proteins and fats should be 55% , 30% and 15%.Not long back people were taking more than 30 00 calories When . on average 10 to 12 chapathies were consumed per day , that itself amounted to more than1800 calories along with side dishes . Apart from that IN BETWEEN NIBLINGS , TEAS , COFFEES , SWEETS , JUNK FOOD ALL contribute to more than 3000 to 4000 calories .If the chapathy consumption comes down to half , junk food is avoided much calorie amount is reduced .But proteins and fats should naturally come down in the same ratio along with the reduced chapathy intake. Thus where is the question of excess proteins.This is a typical Indian meal . North India more of wheat and south India more of rice consumption .The amount of ghee and oils also proportionately comes down . Thus we can have balanced diet in reduced quantities. YOGA , PRANAYAMA , REDUCE THE STRESS and thus compulsive urge to eat more which usually is the outcome of depression. Some herbs give more energy than food .

  • YOU can go for roti of mixed grains consisting of millets ,wheat ,basmathi rice , zo war , kodi etc along with 1/4th quantity of bengal gram dal , all made in to powder in the mixer at home. You can add one table spoon each of flax seeds , black sesame seeds , white sesame seeds and menthi seeds.Add two tea spoons of garam masala made at home ,salt and black pepper powders . While making a roti you add any toppings with carrot , or cabbage or plain onion or shredded pieces of capsicum . This rotti will control your hunger pangs for nearly 6 hours . For lunch you can have another roti. In fact you can add pumpkin seeds , musk melon seeds ,and cashew of pieces also.If made and kept a quantity of 4 kgs you can keep it in an air tight tinand use for one month. In the evening any seasonal fruit with tea can be taken . Night you can take any food which other member,of the family take , but half the quantity . DAILY intake of roti , a seasonal fruit ,two cups of cooked vegetables per day , two cups of curd ,4 almonds , two dates , one dark chacolate ,all will meet the nutritional needs .It takes nearly a month to find out the exact amount of food suitable for your caloric needs .Pranayama further decreases the craving for food while increasing the energy levels .Any change takes some time to settledown . This roti requires only half a tea spoon of oil .The fats which you get in curds, milk , in seasoning of curries and dals will take care of your needs of fat. Try this schedule for a minimum period of 4 months and weight will come down by 6 to 8 kgs with out your noticing of it .Then everything goes as per normal schedule.YOU would never feel that you are deprived of any thing.

  • Initially you may take any medication . Afterwards no medicine is needed . Take only herbal preparations . This is what I recommend to my patients . None of them is under any medication what so ever .But since this is online counceling I suggest you to go to any doctor for monthly check up . Once when the routine sets in you can go for the same once in 3 months .there is no need of monthly check up .

  • Gowardhan

    the degree of BCF is not the same in everybody. So with diet, exercise, yoga and if needed medicine can reverse D. It doesn't mean it got cured. You can keep your numbers under control with these measures.

  • suramo ,

    Do you mean to say , that your preferred diet cures diabetes . It also manages only .But in achieving that, pranayama ,yoga, meditation are more successful .Try to take balanced diet in lesser quantity , do pranayama ,do some asanas , and TRY some herbs like Tinaspora , haritaki , Ocimum . turmeric , Ashwagandha etc and see the result .Pranayama is not breathing exercises and yogasanas are not physical exercises like how many are doing .

  • Total and utter tosh.

    God Almighty, do a margin of research at least and shoot my assertions down with a bit of science instead of scattergun assertions!

  • Really mike 🐒🐒

  • Yes really.

    Come back at me outside of a couple of monkey gifs (whatever that means)

    ...if excessive carb consumption is the cause stopping carb diet should cure the disease. But that doesn't happen.

    Have a pop at this:

  • A day will come when you change your so called scientific beliefs ,the way researches are going on.

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