The immune system goes rogue in the body,

The immune system goes rogue in the body,

They are among the most difficult diseases of our modern age, and their rates are skyrocketing. Beyond the life-sapping symptoms, there’s the element of betrayal. Instead of defending the body, the immune system goes rogue, attacking joints, organs, tissues, even the brain, causing inflammation and destruction. On the simplest level, autoimmune diseases can be viewed as the result of a communication breakdown. For some reason, immune cells lose the ability to differentiate between healthy tissue and disease-causing invaders. In type 1 diabetes, for example, immune cells destroy pancreatic beta cells that produce insulin and keep blood sugar under control.All autoimmune conditions share this theme of self-destruction: Addison’s disease, lupus, celiac disease, Hashimoto’s, multiple sclerosis, rheumatoid arthritis, the list goes on. They’re all a result of attack on specific tissues by an out-of-control immune system.

As many as 23 million people, mostly women, suffer from 80+ types of autoimmune diseases. These conditions often share vague symptoms, at least in the beginning: fatigue, mild fever, difficulty concentrating, allergies, unexplained pains. Misdiagnoses are extremely common and all too often the disease is blamed on psychological factors. For many, a clear diagnosis comes at the end of a long road of struggle and self-doubt.

And once diagnosed, treatment options are limited.

Unfortunately, there is no magic bullet for autoimmune disorders. Most AI therapies are designed to control symptoms rather than address causes — because we still don’t conclusively know what those underlying causes are. Conventional treatments suppress flare ups, and include anti-inflammatory drugs, immune suppressors and other medications — all of which can have significant side effects.

Until recently, many scientists felt that these disorders were caused entirely by genetics. However, continuing research is showing that it’s much more complex. The saying, “genetics may be the gun, but it’s the environment that pulls the trigger” has gained a lot of traction in this field.

There’s increasing evidence that chronic exposure to pesticides, heavy metals and other toxins can increase a person’s risk of developing an autoimmune disorder. For example, lupus clusters have been observed in farmworkers heavily exposed to specific pesticides, and in other areas of increased toxin exposure.

In general, there’s a growing belief among scientists and doctors that our accumulated exposure to toxins is sending the immune system into overdrive, particularly in sensitive individuals.

Researchers have suspected that bacteria and other pathogens may also play a role in AI diseases. In some cases, an infection may start off with a normal immune response, but escalate into an overreaction that becomes chronic.

Other research is showing that bacteria found in the gut, our individual microbiome, may play a significant role in AI diseases. We know that the species of gut bacteria varies greatly between individuals and even cultures (pun intended). One study conducted by Harvard, Sloan-Kettering and NYU showed an association between the bacterium Prevotella copri and rheumatoid arthritis. They found P. copri in 75 % of stool samples from patients who had just been diagnosed with RA, but only in 21 % of samples from healthy people. This is a fascinating area of research which one day may open the door to innovative forms of treatment.

Women are three times more likely to develop an autoimmune condition, and women of childbearing age seem to be at particular risk. Once again, we don’t understand the mechanisms involved, but hormonal influences are suspected to play a role. Toxins are known to bind to estrogen receptors, so there may be hormonal dysregulation fueling the reaction.Stress may also be a factor, triggering cascades of pro-inflammatory hormones. Women who are juggling career, family, etc. are particularly at risk for the type of chronic stress that keeps the body in overdrive mode, which in turn may contribute to autoimmune conditions.On a mind-body level, modern society pushes women to be more critical of themselves and to sacrifice their own needs. When viewed from a holistic perspective, this type of “self-sabotage” is similar to what’s happening on a cellular level in AI diseases. Being mindful of this burn-out risk, and taking time to practice loving self-care, can benefit people struggling with autoimmune conditions — both men and women.

With limited conventional treatment options — none of which address root causes — a holistic approach is an important part of effective AI management. This includes diet, exercise, stress reduction, trigger avoidance and targeted supplementation.

An anti-inflammatory diet and lifestyle form the basic foundation for health — in AI disease, this approach is a must. Emphasize organic produce and meats, lean protein, lots vegetables, some brightly colored fruits, healthy fats, raw nuts and seeds, and unprocessed foods. I particularly recommend cruciferous vegetables, which when metabolized, produce a compound called DIM that helps maintain hormone balance. In addition, cruciferous vegetables such as broccoli, chard, kale and cabbage are excellent detoxifiers. A recent study found that a drink made from broccoli sprouts helped remove the highly prevalent toxin, benzene.

Sugar is inflammatory, so be sure to limit intake as much as possible. The same is true of alcohol, caffeine and gluten, as well as processed foods full of inflammatory chemicals.

Addressing food sensitivities/allergies is also a must, as certain foods can be powerful inflammatory triggers that damage the protective gut lining where much of our immune activity takes place. An elimination diet is a good first step, but this is an area best explored with a qualified healthcare provider.

September 29, 2015 | Dr. Isaac Elia z


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