Disease Dangers of Chronic Inflammation

Disease Dangers of Chronic Inflammation

Nutritional factors may contribute to – and may thus counteract – the unchecked inflammatory response.

Posted on Sept. 22, 2015, 6 a.m. in Inflammation Nutrition

- An unresolved inflammatory response is likely to be involved from the early stages of disease development. Controlling inflammation is crucial to human health and a key future preventative and therapeutic target. In a recent ILSI Europe's article published in the British Journal of Nutrition, a coalition of experts explain how nutrition influences inflammatory processes and help reduce chronic diseases risk.

Inflammation is a normal component of host defence, but elevated unresolved chronic inflammation is a core perturbation in a range of chronic diseases. Prevention or control of low-grade inflammation therefore seems to be an attractive target effect for healthy food or food ingredients. In a recent article commissioned by the ILSI Europe Obesity and Diabetes Task Force, experts present new approaches to capture inflammatory status in humans and to help quantify how much diet can positively modulate inflammation.

"Inflammation acts as both a friend and foe, being essential in metabolic regulation, with unresolved low-grade chronic inflammation being a pathological feature of a wide range of chronic conditions including the metabolic syndrome and cardiovascular diseases", commented Prof. Anne Marie Minihane, University of East Anglia (UK).

The nutrition status of the individual with for example a deficiency or excess of certain micronutrients (e.g. folate, vitamin B12, vitamin B6, vitamin 1, vitamin E, zinc) may lead to an ineffective or excessive inflammatory response. Studies have showed that high consumption of fat and glucose may induce post-prandial inflammation (manifesting itself after the consumption of a meal), which may have consequences for the development of diabetes and cardiovascular diseases. The Western-style diet, rich in fat and simple sugars but often poor in specific micronutrients, is linked to the increased prevalence of diseases with strong immunogical and autoimmune components, including allergies, food allergies, atopic dermatitis and obesity.

Anne M. Minihane, et al. Low-grade inflammation, diet composition and health: current research evidence and its translation. British Journal of Nutrition 2015; published online. The study authors submit that: “the ability of diet to positively modulate inflammation and provide the much needed evidence to develop research portfolios that will inform new product development and associated health claims.”

To read the publication, click here: journals.cambridge.org/acti...

4 Replies

  • If you are a diabetic petient, lower your blood sugar to a normal level. 9fbs ,100 mg/dL, PPBS < 140 mg/dL.)

    Chronic inflammation may lead to amputation of the leg. Also beware of necrotizing fasciitis (flesh eating bacteria).





  • gangadharan_nair

    does it mean that merely controlling bsl is not sufficient,it also necessary to reduce chronic inflammation?How does one go about ?

  • Antibiotics have no effect unless you control your blood sugar.

  • Get insulin level in blood down which also means getting TG down to less than 100. Low Carb High Fat diet doesn't cause inflammation. It reduces it. Check it out with any of the 400+ Indian diabetics on LCHF diet :)

    It's the carbs that has caused all the problems and so called experts blame FAT without even a single scientific evidence from real world. The western diet has never been rich in FAT for decades but it's rich in CARBS ever since USDA started pushing a FAILED Pyramid.

    High CARB diet stimulate hepatic SFA synthesis and conservation of dietary SFA. So, culprit is HIGH CARB and not FAT. Cut out hepatic SFA synthesis and start burning FAT. This can only happen on LCHF diet.

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