reversing diabetes -new castle university


New castle Magnetic Resonance centre is an affiliate of New Castle University in United Kingdom.They have published an article on the topic of diabetic 2.The article highlights essentially the following

1.our body has different levels of tolerence for fat in liver and pancreas Too much fat withinin lever and pancreas affects normal action of insulin and insulin secretion.Both are reversible.

3 In people whohave had diabetes for four years or less major weight loss returns insulin secretion to normal

4 Diabetes is not inevitably progressive or life long

I am posting here the full text of the article “Reversing type 2 Diabetes”for detailed reading by those who are interested.

“Newcastle Magnetic Resonance Centre

Reversing Type 2 Diabetes

Our work has shown that type 2 diabetes is not inevitably progressive and life-long. We have demonstrated that in people who have had type 2 diabetes for 4 years or less, major weight loss returns insulin secretion to normal.

It has been possible to work out the basic mechanisms which lead to type 2 diabetes. Too much fat within liver and pancreas prevents normal insulin action and prevents normal insulin secretion. Both defects are reversible by substantial weight loss.

A crucial point is that individuals have different levels of tolerance of fat within liver and pancreas. Only when a person has more fat than they can cope with does type 2 diabetes develop. In other words, once a person crosses their personal fat threshold, type 2 diabetes develops. Once they successfully lose weight and go below their personal fat threshold, diabetes will disappear.

Some people can tolerate a BMI of 40 or more without getting diabetes. Others cannot tolerate a BMI of 22 without diabetes appearing, as their bodies are set to function normally at a BMI of, say 19. This is especially so in people of South Asian ethnicity.

Information for people with diabetes

•Download the information leaflet: Reversing Type 2 Diabetes (PDF: 286KB)

•Get sample vegetable recipes and meal plans from the Reversing Diabetes Low Calorie Diet Programme (PDF: 375KB) devised by Miss Karen Heron, Dietician, Newcastle Diabetes Centre. More information on low calorie diets is available from the Diabetes UK website.

•The British Heart Foundation provide advice on weight loss.

•Read Richard Doughty's personal story Type 2 diabetes and the diet that cured me on the Guardian website, including a video interview of another personal story and an update from Richard, I reversed my diabetes in just 11 days, on the Mail Online.

Information for your doctor

It is important that people with diabetes discuss their management with their own doctor. It will take years for this new knowledge to become incorporated into textbooks and guidelines, so your doctor may be wary of information from the internet.

Newcastle University researchers have written some notes for you to take to your doctor. Download our information sheet for doctors on the practical management of type 2 diabetes in respect of reversal (PDF: 220KB).

Further Reading

•In 2008, we published the Twin Cycle Hypothesis to explain the cause of type 2 diabetes. This hypothesis predicted that diet could entirely reverse type 2 diabetes. Read our scientific review, Pathogenesis of type 2 diabetes on the US National Library of Medicine website.

•A clinical study designed to test the hypothesis was funded by Diabetes UK. The results were very clear. Weight loss averaging 15kg (2 stone 5lb) achieved over 8 weeks caused two distinct sets of changes. Within 7 days, liver fat had fallen by 30%, liver insulin sensitivity had returned to normal and fasting blood glucose had become normal. By 8 weeks, pancreas fat content had returned to normal and insulin secretion by the pancreas had returned to normal. Read the full scientific paper, Reversal of type 2 diabetes and the related Newcastle University Press Release, Diet Reverses Type 2 Diabetes.

•This new understanding of what causes type 2 diabetes and how it can be completely reversed has been used by individuals worldwide, a report has been published documenting practical management of type 2 diabetes in respect of reversal (PDF: 84KB).

•Professor Taylor was awarded the 2012 Banting Lectureship of Diabetes UK. Read his lecture Reversing the twin cycles of Type 2 diabetes (PDF: 543KB).

•Scientists and doctors with access to the journal Diabetes Care, can read a full review of the science underlying this matter: Type 2 diabetes: etiology and reversibility.

22 Replies

  • If you could provide link to this study, that will be helpful. Thanks and regards

  • This can only be done under "MEDICAL SUPERVISION"


    newcastle university 800 calorie diet

  • ragivji,

    this result is their second confirmation after their first trial. i mean the famous newcastle university 600 calorie diet .

    though it is called world wide 600 calorie diet ,

    in actual practice they had given 800 calories per day.but the name 600 calories got stuck.

    doesnt matter the calories--

    i think a slower reduction in weight also will work out.

    the point is :

    reduce weight.

    you have done a great complementary work in bringing out this paper . congrats.

    good luck

  • Is the diet available

  • there is enough discussion on weight loss diet in this forum -lower calorie intake than your present may help. Consult your doctor/dietition

  • My daily consme 800- 1000 calories since last 1 1/2 years my wt reduced 64 kg to 56 kg Hba1c 5.8 special cicumstances atending unctions it may somr more on that days

  • the diet may be

    the usual healthy mans diet with limited calories so that weight falls.

  • It has been known that reduction of fat in liver and pancreas in many cases reduces blood sugar. Indiacratus was saying so since long.

    Here I have some queries for discussion purpose only.(1) Usually diabetes is diagnosed ,at least in India,either at a routine blood test for other ailments ,or many many years after the disease has afflicted a person or a diabetic complication has set in. In that case is it possible to reverse the diabetes.

    (2) what are the symtoms of excess fat in pancreas and/or liver. Unless one suspects that there is fat, no test will be done to detect or confirm it

  • dear patliputra,

    the last paragraph in your response is the crucial issue.

    probably with the magnetic resonance method =MRI

    they found it out.


    New castle Magnetic Resonance centre is an affiliate of New Castle University in United Kingdom.]]

    may be that there may be a special mri procedure.

    reducing weight is good for general health not to speak of diabetes.

    good luck

  • I have further details. since you said long article no one will read I shortened .It is true that MRI has detected this

  • After reading the complete article,it appears that weight loss is the main reason behind the reversal of diabetes. Therefore it can be concluded that , it is only applicable to or effective in obese diabetics.

    It is not possible for general populace to follow and adhere to that diet of 600/800 calories with so much restrictions.

    This study ( only 11 persons) is very small and of very short duration (8 weeks ).

    Genetic variations of different races have not been taken into consideration, so it has got no international appeal.

    Long term effects unknown.

    Result was not unequivocal as only 8 out of 11 showed reversal of diabetes after 3 months evaluation.

    Weight reduction and sub calorie diet is known to reduce blood sugar.

    The whole experiment does not call for over enthusiasm.

    But compliments for bringing it out in open for discussion.

  • What you have said is not after complete study.Since you had said you did not feel comfortable to read long posts,i posted only part of research. The other part was posted in another post titled "twin cycle hypothesis where it mentiond long term effect. Kindly read both together for the correct conclusion

  • I have read both your articles. Twin cycle hypothesis is different from new castle experiment. They are talking about long term effects after barriatic surgery.

    I will be happy if you can point out the ref. line or paragraph of long term effects of new castle experiment.

  • Hence, for a given individual with type 2 diabetes, reducing the liver and pancreas fat content below his or her personal trigger levels would be expected to result in a release from the fatty acid–mediated dysfunction. Individual tolerance of different degrees of fat exposure vary, and understanding this liposusceptibility will underpin the future understanding of genetically determined risk in any given environment. However, this should not obscure the central point: If a person has type 2 diabetes, there is more fat in the liver and pancreas than he or she can cope

  • Pataliputra

    I have reproduced the para.The bariatric surgery lead them to further research and found the twin cycle phenomenon.. I feel the concluding part refers to this aspect and not the bariatric surgery alone. If diet can reduce weight this phenomena will automatically reduce diabetic symptoms which will reoccur with weight gain. again. As long as diet is under control diabetes also will be under control. This is my understanding .I stand corrected. Long grain wheat formula of shooter George appears to be based on this understanding. He has proved diabetes has not reoccurred in his own case..

  • So, where is long term effects of new castle experiment ? You are simply trying to correlate the pathogenesis. I don't want to be rude, but please first understand the queri before you put your comment.

  • You can be rude.If you wish to.. The article itself expects us to down load. lot of further info I feel it is lot of work for me just to answer your querry. .You are at liberty to hold on to your understanding.

    thanks for your reaction


  • BMI index could prompt a person to get his health checked before the diabetic symptoms develop noticeably. Many industrial and govt organisations finance for annual health check up of their employees.Fatty liver can be detected by sonograhy as part of annual check up.

  • said theory is still under aprooval in WHO for want of study report,

  • thanks. This information is very useful. Why don't you participate more increasingly in this forum?As a cardiac surgeon you can definitely contribute.

  • The full text of the research paper written by Mr Roy Tailor M.D.FRCP of magnetic research centre of new castle university on the subject has been published in the journal of American Diabetic Association 'Diabetic care". The research article consists of several pages with charts and diagrams and those who wish to read can do so by visiting .36/41047.Full

    Mr Roy Tailor's email address is

    My posts have to be understood to provoke interest on the topic and by no means all that is in full in the research . Instead of putting embarrassing questions to me and using rough language they can download the full text available free in pdf format and find answer to their doubts themselves. What I have said here, in my feeling ,is essentially correct.

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