How does body transport glucose to body cells?A researcher speaks
According to research,,a major mediator of glucose removal from the circulation and a key regulator of whole-body glucose homeostasis.is the GLUT4 a protein that mediates this uptake and is one isoform (Gene name, SLC2A4; protein name: GLUT4) of a family of sugar transporter proteins.
It is stated that in case of non diabetecs elevated glucose levels are rapidly returned to normal even after huge caloric ingestions, and they are maintained at only slightly lower levels during long-term starvation.
Such control prevents severe dysfunctions such as loss of consciousness due to hypoglycemia and toxicity to peripheral tissues in response to the chronic hyperglycemia of diabetes.
The major cellular mechanism for disposal of an exogenous glucose load is insulin-stimulated glucose transport into skeletal muscle. Skeletal muscle both stores glucose as glycogen and oxidizes it to produce energy following the transport step.
The principal glucose transporter protein that mediates this uptake is one isoform (Gene name, SLC2A4; protein name: GLUT4) of a family of sugar transporter proteins containing 12-transmembrane domains. The GLUT4 glucose transporter is thus a major mediator of glucose removal from the circulation and a key regulator of whole-body glucose homeostasis.
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