I'm trying to help my mother with PD. This is one of the questions I noted down. I couldn't find any answer on this particular question yet.
High dose of vitamin B1 (thiamine):
If a person takes a little too much, a temporary worsening of symptoms happens. According to Dr Constantini's protocol; this are symptoms of an overdose.
In this particular situation, one should take a break and then reduce or halve the dose.
When he/she has found the right dose and experiences improvement, then possibly after a month or so a worsening of symptoms may occur again. He/she should take another break and then reduce the dosage. So one takes less and less over a longer period of time.
But how far does this process go? Does this mean that there will be a time, after many reductions, when B1 can no longer?
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No, the object is to reduce the dose until no overdose symptoms are seen and then you know the dose is very close or optimal if you are getting symptom improvement and a good response on the pull test.
I mean after you find the optimal dose do you still need to reduce b1 over time?
For example, a member of this forum said that she found the optimal dose or close to it (with symptom improvement) and still had to reduce her dose after a period of time (a month or so). And this seems to be a continous process..
I have gone from 100mg sublingual B1 daily to a current dose of 25mg every fifth day. I think this is a twentieth of my original dose. I have not planned to reduce. I’ve been guided by recognising worsening symptoms as overdose and adjusting down. I have maintained all the improvements that B1 brought me by doing this. But hey, we’re all experimenting and trialling. I’m in my 6th year of B1 but that isn’t long for us to gain information about long term B1 therapy use. I believe Roy P is taking a different route. When his symptoms worsen he increases his B1 dose. However, I think I’m right in saying that his symptoms have worsened, he has reported his tremor is worse, and his medication dose has increased. Roy doesn’t believe in the possibility of overdose.
Nobody can answer categorically. We are so different.. This therapy is just experimental and not supported by real clinical trials. So Dap is right, at this stage simply experimenting and trialing..
"But how far does this process go? Does this mean that there will be a time, after many reductions, when B1 can no longer?"
I don't think so. From my reading of Dr C, I don't think he was suggesting that a patient would decrease and get to zero.
In my experience, lowering my husband's dose didn't help. We went from 2500mg to 500mg, slowly, and he got worse all along. I slowly raised his dose to 3000mg and he's improved.
You may or may not need to decrease your Mom's dose.
Glad chartist posted links to answer your question.
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