Eat broccoli sprouts for metabolic syndrome - Surface Your Real Selfsurfaceyourrealself.com/202... “Insulin resistance is one of the defining clinical traits of metabolic syndrome, which represents a constellation of metabolic disorders, mainly comprising obesity, type 2 diabetes mellitus, atherogenic dyslipidemia, and hypertension. This study aimed to investigate therapeutic effects and potential mechanisms of sulforaphane (SFN) on high-fat diet (HFD)-induced insulin resistance. Control chow diet was 10 kcal% fat, and HFD was 60 kcal% fat. SFN was found to effectively reduce body weight, fasting blood glucose, and hyperlipidemia, and improve liver function in HFD-fed mice. SFN led to increased expression of antioxidant genes downstream of Nrf2, and decreased accumulation of lipid peroxides MDA and 4-HNE. SFN significantly reduced glutathione peroxidase 4 (GPx4) inactivation-mediated oxidative stress by activating the AMPK and Nrf2 signaling pathways. Data suggested that GPx4 could be a key target through which SFN might activate Nrf2/ARE signaling pathway to decrease the extent of insulin resistance induced in HFD-fed mice. Taken together, SFN ameliorated HFD-induced insulin resistance by activating the AMPK-Nrf2-GPx4 pathway, providing new insights into SFN as a therapeutic compound for alleviation of insulin resistance.”
There seems to be a connection between insulin resistance and PD. One example: Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling ncbi.nlm.nih.gov/pmc/articl...
So I'm thinking fixing insulin resistance is a good thing.
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In general mice do poorly on a high-fat diet because their wild diet is typically only 10 percent fat. Be that as it may, glad the sulforaphane fixed it.
I should have elaborated. There seems to be a connection between insulin resistance and PD. One example: Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling ncbi.nlm.nih.gov/pmc/articl...
So I'm thinking fixing insulin resistance is a good thing.
In March I joined a 16-week Keto weight loss program. I had read that insulin resistance in the brain had been linked to neurogenic diseases such as PD. I was not overweight at that time, and my blood glucose was and still is in the normal range. I was looking for a metabolic reset in the brain. That program ended in July. I’m still on Keto. I’m also taking SFN, experimenting with dose and frequency. It’s been an interesting journey. And it’s not over.
so are you seeing improvements from the keto diet? Did you lose weight on it? I have read that the keto diet can create some problems if maintained over a sustained amount of time with things like bone health and kidney stress
I believe Keto has helped my PD symptoms. Yes I did lose weight. I went from my normal weight of 168 down to 152 in a matter of weeks. Hydration and Mineralization are important to monitor. If you’re going to try it, I suggest you take advantage of some professional help. There’s a group called “Bio-Intelligent Wellness” that seems to have a good support system. The program I was on was monitored by my local MD. It can be found online at “IdealProtein.com”. Good luck, I hope this helps - JG
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