Lithium for Parkinson's Book Coming in Oc... - Cure Parkinson's

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Lithium for Parkinson's Book Coming in October

Bolt_Upright profile image
50 Replies

Update 7/15/22: I should have noted that the trial is using Lithium Aspartate, not Lithium Orotate. I e-mailed the doctor asking if Lithium Orotate would be as good and he said it should not make a difference. There were some rat studies linking Lithium Orotate with cancer so they went with Aspartate.

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So... I might be getting ahead of my skis here, but this is kind of curious:

Dr. Thomas Guttuso, Professor of Neurology, University at Buffalo is conducting the "Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease" trial clinicaltrials.gov/ct2/show... Estimated Study Completion Date : July 1, 2022

Dr. Thomas Guttuso, Professor of Neurology, University at Buffalo also has a book coming out.

The Book, "The Promise of Lithium: How an Over-the-Counter Supplement May Prevent and Slow Alzheimer's and Parkinson's disease", is currently scheduled to be available on Amazon in October 2022. promiseoflithium.com/

I'm not saying the trial was a success. I don't know. But... I am going to keep taking my 15 mg of Lithium Orotate.

Additional Reading:

Parkinson’s Disease: Potential Actions of Lithium by Targeting the WNT/β-Catenin Pathway, Oxidative Stress, Inflammation and Glutamatergic Pathway 2021 ncbi.nlm.nih.gov/pmc/articl...

Potential application of lithium in Parkinson's and other neurodegenerative diseases 2015 frontiersin.org/articles/10...

50 Replies
Bolt_Upright profile image
Bolt_Upright

I should say that I have not been diagnosed with PD. I have REM Sleep Behavior Disorder, which my doctor says will turn into PD. I also have a sore left shoulder, sore left left, and some involuntary muscle movements.

Also, I take a number of things. My shoulder does seem to finally be getting better and I have less muscle jerks, but who know. I hope to halt things where they are.

Here is a great video on low dose Lithium: youtu.be/J7VB6fOh9XE

Gioc profile image
Gioc in reply to Bolt_Upright

In my opinion, adding lithium without medical supervision does not seem like a good idea to me, especially in conjunction with other antidepressants. Bipolar disorder is not PD. If you think have PD your medication is or will be levodopa.This is because the dopamine-producing tissue in the brain is partially lost in a Parkinson's patient. PD is more a matter of brain anatomy, given the injury, than a general imbalance of the chemical processes of the brain and the whole body.😜

wifeofparky profile image
wifeofparky in reply to Gioc

It is a much lower dose than what is prescribed for Bipolar disorders. I was at a symposium where Dr Guttuso presented his early study. He is seeking grants to expand the study to include more participants to validate the hypothesis and determine the lowest effective dose. Dr. Guttuso was my husband's MDS.

LindaP50 profile image
LindaP50

Thank you for this post. I don't recall reading anything on Lithium previously. Perhaps I wasn't interested at the time but this post caught my attention.

wifeofparky profile image
wifeofparky in reply to LindaP50

I attended his presentation on Lithium therapy. He has completed a lot of research on this and I look forward to further studies. Also his research study was done on PD patients not on animals.

LindaP50 profile image
LindaP50

I have a question. Why doe the doctor think REM will turn into PD?

Bolt_Upright profile image
Bolt_Upright in reply to LindaP50

Because statistically 50% of people diagnosed with RBD are diagnosed with PD within 5 years. 90% within 12 years.

LindaP50 profile image
LindaP50 in reply to Bolt_Upright

Do you know why?

Bolt_Upright profile image
Bolt_Upright in reply to LindaP50

Sorry, I don't know why. A lot of doctors believe RBD is an early symptom of PD (or LBD or MSA).

MarionP profile image
MarionP in reply to Bolt_Upright

Now that is an interesting statistic.

Any possibility of getting a source of actual numbers, samples, validity or any study along those lines of that claimed statistical association so people can have a look for themselves? Because when someone is claiming or using the term "statistically" then those statistics must be available somewhere for examination, or the person would not be able to say "statistically" in the first place.

Bolt_Upright profile image
Bolt_Upright in reply to MarionP

Just Google "REM Sleep Behavior Disorder Parkinson's" and the articles and statistics will come up. I would do it but I have already seen the papers and it depresses me to see them.

MarionP profile image
MarionP in reply to Bolt_Upright

It does, huh? Then this will pull you out of it.

science.org/content/article...

Bolt_Upright profile image
Bolt_Upright in reply to MarionP

Men lose Y chromosomes as they age. It may be harming their hearts

Study in mice is first to directly test health effects of losing male chromosome

?

MarionP profile image
MarionP in reply to Bolt_Upright

I just liked the headline title

Gioc profile image
Gioc in reply to Bolt_Upright

IMO se noi potessimo portare la vita media a 200 anni statisticamente il 100% delle persone contrarrebbero prima il PD poi l’alzheimer. Lo so che è una stupidaggine, ma la scrivo per farti riflettere su quanto sia lontano dal contesto reale questo “statisticamente “. Non lo traduco.

Traslation Addition

IMO if we could bring the average lifespan to 200 years , statistically 100% of people would contract PD first and then Alzheimer’s. I know it’s nonsense, but I write it to make you think about how far this “statistically” is from the real context.

Greetings from Italy
LindaP50 profile image
LindaP50 in reply to Gioc

Don't know what you posted but I do like the serene picture. 🙂

Bolt_Upright profile image
Bolt_Upright in reply to LindaP50

From Google Translate: IMO if we could statistically bring the average life to 200 years, 100% of people would contract first PD then Alzheimer's. I know it is nonsense, but I am writing it to make you reflect on how far this is "statistically" from the real context. I don't translate it.

Bolt_Upright profile image
Bolt_Upright in reply to Gioc

Grazie.

bassofspades profile image
bassofspades

read.amazon.com/kp/embed?as...

My physician insisted that I read this book and start on Lithium as a therapy for PD. It has been nothing short of a miracle, as I have explained in numerous posts on this site. Feel free to search them, I have explained it to death! Any questions you have about the subject are answered in the book.

Read it!!!

Bolt_Upright profile image
Bolt_Upright in reply to bassofspades

One question please: Do you believe Lithium has stopped or slowed your progression? (You could also answer reversed).

bassofspades profile image
bassofspades in reply to Bolt_Upright

Yes, it certainly helped. The biggest benefit I get from it is the total reversal in my chronic brain fog. The only supplements I take anymore are 15mg Lithium Oratate, sublingual B1 and a Magnesium supplement. And believe me, I tried nearly everything!

The other thing that helps me with PD is getting 8 hrs sleep a night, (for me, now with a CPAP) , and intermittent fasting. These things activate the body's natural garbage recycling action and clear unwanted proteins, from which PD related problems can stem from.

Bolt_Upright profile image
Bolt_Upright in reply to bassofspades

That is very cool that you are down to 3 supplements!

MarionP profile image
MarionP in reply to bassofspades

Another very interesting response.

Ghmac profile image
Ghmac in reply to bassofspades

Where do you get sublingual B! and what dose do you take?

Ghmac profile image
Ghmac in reply to Ghmac

What type of lithium do you take?

bassofspades profile image
bassofspades in reply to Ghmac

oratate

bassofspades profile image
bassofspades in reply to Ghmac

B1, 100mg I get it wherever its cheapest. usually amazon

SilentEchoes profile image
SilentEchoes

Talk to me about your "muscle jerks" are they myoclonic seizure type? I have them in addition to fasciculations (two very different involuntary movements).

SE

Bolt_Upright profile image
Bolt_Upright in reply to SilentEchoes

I think I have both fasciculations and myoclonic jerks. Usually it is something like my foot moving at the ankle. I'd say it happens a couple times a day.

MarionP profile image
MarionP

very interesting study hypotheses. Will be looking forward to reading about it with some interest, as well as the upcoming publications. Doses indeed are quite quite low compared to uses of lithium in psychiatry. Of course the lithium preparations listed are controlled by prescription, and not the same thing at all as the one form of lithium available without a prescription, lithium Orotate.

Is this something you're going to be hanging on to and following?

Bolt_Upright profile image
Bolt_Upright in reply to MarionP

I started taking Lithium back in March. I plan to keep it up.

JustJeff profile image
JustJeff

Really interesting particularly as it is found in exanatide which is in stage 3 trials :)

JustJeff profile image
JustJeff

Hi Bolt where do you buy your 15 mg of Lithium Orotate from thanks

Bolt_Upright profile image
Bolt_Upright in reply to JustJeff

amazon.com/gp/product/B01FM...

dvoranel profile image
dvoranel

Hi Bolt. Thank you so much for posting. How did you decide on dose of 15 mg rather than 5 or 20?

Bolt_Upright profile image
Bolt_Upright in reply to dvoranel

15 mg is the low dose in the trial.

Jebbie12 profile image
Jebbie12

I’ve been taking 20 mg of lithium a day for 2 1/2 years, much less then the dosage for bipolar and similar disorders.. I am 13 years into my disease, and I am still going strong. I teach yoga once a week and exercise every day, including a 1 mile walk. Dr. Laura Mischley in Oregon is very knowledgeable about Lithium being used for Parkinson’s. She had my lithium levels tested, and they were very low. She has a wealth of information on her website. Google her name and check her out!

JCRO profile image
JCRO in reply to Jebbie12

Mischley’s MPH was on Lithium Orotate and PD. Her PhD on intra nasal Glutathione for PwP. I think that’s the right way round. She is working on a new project with MJFF on the benefits or otherwise of another supplement for PD (7/20222). I’ve also been taking 20mg of Lithium Orotate for 2.5 years.

Boscoejean profile image
Boscoejean in reply to JCRO

so what is the new supplement that Laurie Mischley is studying? Her Parkinson summer school is at Bastyr in Washington state or at least it has been there. (Kenmore, WA by Seattle) She is a naturopath and there are other naturopaths that have been advocating low dose lithium for some time. tahomaclinic.com/2010/05/li...

JCRO profile image
JCRO in reply to Boscoejean

Let me confirm. I “think” I know but don’t want to mislead.

LindaP50 profile image
LindaP50 in reply to Boscoejean

Oh, WOW! Sparked my interest even more when I read, "n addition to the benefits routinely mentioned, like controlling gout and relieving rashes caused by sebhorric dermatitis, lithium also has some great brain-boosting effects."

I get sebhorric keratosis and more so will definitely try this for me and getting brain-boosting effects is a plus. Will definitely purchase for me and my hubby (PWP). All my dermatologist recommended was a cream for "bumpy skin" which works OK not great.

Thanks for this post!!!

Bolt_Upright profile image
Bolt_Upright in reply to LindaP50

Thank you! I did not even notice the part that said it relived relieving rashes caused by sebhorric dermatitis!

Bolt_Upright profile image
Bolt_Upright

I should have noted that the trial is using Lithium Aspartate, not Lithium Orotate. I e-mailed the doctor asking if Lithium Orotate would be as good and he said it should not make a difference. There were some rat studies linking Lithium Orotate with cancer so they went with Aspartate.

JayPwP profile image
JayPwP

Bolt, do you take LO before, after or with food?

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

I take it first thing in the morning. I may or may not eat soon after. I may not be doing this right.

JayPwP profile image
JayPwP in reply to Bolt_Upright

How were you taking LO when you were also taking MB?

I am asking because I am expecting MB and LO to be delivered over the next two weeks.

Bolt_Upright profile image
Bolt_Upright in reply to JayPwP

I would have my MB first thing in the morning. Then my supplements soon after. I just try to get as much out of the way as possible first thing in the morning (which is about 10:30 AM for me) :)

JayPwP profile image
JayPwP in reply to Bolt_Upright

Thanks Bolt

JayPwP profile image
JayPwP in reply to Bolt_Upright

Dear All,

LO 5mg bottle received today. Would like to start from Saturday.

I should take it first thing in the morning on an empty stomach?

What signs and symptoms should I be looking out for? Any help with the dosing regiment?

Your views are solicited

nickmiller profile image
nickmiller

Some of the most popular programming languages of 2022 include Python, Java, C, JavaScript, C++, C#, PHP, R, and Swift. more there mlsdev.com/blog/54-benefits...

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