CITICOLINE - A Nice Blog

[John_morris71]

Found this on the web. Hope you guys like it

hvmn.com/blogs/blog/supplem...

[Bolt_Upright]

Citicoline as Adjuvant Therapy in Parkinson's Disease: A Systematic Review 2021 pubmed.ncbi.nlm.nih.gov/332...

" Abstract

Purpose: Parkinson disease (PD) medications are not readily available in all countries. Citicoline increases dopamine synthesis and inhibits dopamine uptake. This systematic review aims to synthesize current existing evidence on the efficacy of citicoline adjunctive therapy in improving PD symptoms.

Methods: An extensive literature search of Scopus, Embase, PubMed, Cochrane Library, and Google Scholar was conducted for articles published on or before December 31, 2019. The studies were screened and selected by 2 independent reviewers. We included all studies that explored the efficacy of citicoline as an adjunct therapy in PD.

Findings: A total of 7 studies (2 crossover, 3 randomized controlled, and 2 open prospective studies) were included. Despite the varied outcome tools, this review found that patients with PD who were taking citicoline had significant improvement in rigidity, akinesia, tremor, handwriting, and speech. Citicoline allowed effective reduction of levodopa by up to 50%. Significant improvement in cognitive status evaluation was also noted with citicoline adjunctive therapy.

Implications: Citicoline adjuvant therapy has beneficial effects as an adjuvant therapy in patients with PD. However, due to the heterogeneity of the studies, there is a need for more high-quality studies.

"

[park_bear in reply to Bolt_Upright]

In my review of cardiotoxicity arising from choline supplementation due to generation of TMAO, I was unable to find any evidence either way with regard to citicoline. Citicoline, in common with choline, does have the trimethylamine chemical structure, so that is a possibility.

From my blog at KosAbility:

Choline And Carnitine Supplementation Can Be Cardiotoxic

tinyurl.com/2p8jjuf8

[John_morris71 in reply to park_bear]

Thanks. I am planning to give my mother Citicoline.

I was wondering if a total of 2 doses of 500mg each , once in the morning and then in the evening is going to be too much to begin with. Given that PD is a disease that is related to Mitochondrial dysfunction, does this make it kind of OK to give Citicoline.

Saw this too.

researchgate.net/publicatio...

[park_bear in reply to John_morris71]

Yes I did see that:

"It is hypothesized that, compared to choline moiety in other dietary sources such as phosphatidylcholine, choline in citicoline is less prone to conversion to trimethylamine (TMA) and its putative atherogenic N-oxide (TMAO)."

[Emphasis added]

I am skeptical because both choline and phosphatidylcholine, which are relatively small and large molecules respectively, both suffer from conversion to TMA/TMAO.

I am not able to suggest a proper dosage at this point.

[John_morris71 in reply to park_bear]

I understand. My mother is definitely showing signs of cognitive decline. (She just completed 78 years yesterday). So I have to take some balanced risk ( if at all the term makes sense) of giving her citicoline to try and arrest the decline, if not reverse it. Will probably start with 250mg dose, twice a day for a month or two to see how it goes.

I am also contemplating on trying Mitopure - 1000mg/day @ 2 doses of 500mg each. Again, will be taking a chance here, under the ASSUMPTION that it can induce Mitophagy and thereby repair the Mitochondria, (especially the cleaning up of degraded Mitochondria, by restoring the mechanism doing it). Mitophagy is driving my decision. (also the fact that Mitopure crosses the BBB). I am aware that not much research is being done on Mitopure and its benefits to cognition/brain. But do not have time to wait for some paper to be published.

Not an easy decision for sure.

All this, while I am going move some other supplements from a daily to alternate day regimen, if I decide to go ahead with Citicoline and Mitopure. (Plan is to give these for about 3 to 4 months).

[park_bear in reply to John_morris71]

I understand as well. Presumably you have already tried or considered high-dose thiamine. Cinnamon is another intervention to look at. My report here:

healthunlocked.com/cure-par...

[John_morris71 in reply to park_bear]

Gave Ceylon Cinnamon for almost 5 years and have discontinued it since almost a year. Also giving 1000mg of Thiamine for more than 2 years now.

[Dap1948 in reply to John_morris71]

You say you have been giving your mother 1g B1 for a long time. Did you experiment with other doses to establish that 1g was the right dose for her? Did this dose improve symptoms? If it was not the correct dose for her it would probably have had no benefit. It needs to be the dose which, for her, triggers enzymes to spring back into action. All in my book “Parkinson’s and the B1 therapy” available on all amazons.

[John_morris71 in reply to Dap1948]

Yes, I have tried different doses, higher and lower than 1 g/day and found that 1g/day is the appropriate dose. I do not have to time to experiment, to establish the optimal dose down to the mg level - all this knowing that B1 won't cure the ailment. Does your book address the right dose to cure PD (and nothing less)? Let me know.

[kevowpd in reply to John_morris71]

Can you point to the evidence that convinced you to try B1 in the first place?

It won't cure PD or stop its progression.

[John_morris71 in reply to kevowpd]

Read a lot about it. More than evidence, it is faith/hope - that last resort. I had her blood test reports that showed very low B1 too. So that was another reason. I know that it wont cure PD or stop its progression, but hopefully it can slow down the progression. Buying time is also a strategy. She was basically bedridden almost 9 years back riddled with pain and depression/lack of sleep and host of other symptoms including constipation, and now she can walk for 30 minutes nonstop, even though she needs help in most of her daily tasks even as many symptoms have disappeared. So I will take that as an improvement.

[Hidden in reply to John_morris71]

Have you considered Ambroxol or Montelukast? And I second Arts Vinpocetine recommendation from personal experience.

[Dap1948 in reply to kevowpd]

I haven’t increased my medication for seven years. I’d call that B1 pretty well stopping progression!

[kevowpd in reply to Dap1948]

I wouldn't. There are people who don't use any meds at all for years post dx. Doesn't mean their PD isn't progressing.

[Dap1948 in reply to kevowpd]

My neurologist wrote in her report that there had been no progression for several years. She tested for rigidity and bradykinesia and said she could find none any more and that I looked very well. I was diagnosed 12 years ago. I’m thanking B1!

[kevowpd in reply to Dap1948]

healthunlocked.com/cure-par...

Just feel grateful, John, that you have done as well as you have. It is very hard to say with confidence that a or b is the absolute reason why you have been so fortunate.

Would the same not apply here? That it's difficult to say that a or b are the reason? And weren't you an ardent follower of John's, including hosting him at your home? Couldn't it be the fast walking that has stopped your progression?

Exercise, and walking specifically, helps people but many have found that even following your instructions, it hasn’t slowed down their PD progression.

Sounds a lot like B1, no?

[Dap1948 in reply to kevowpd]

Also B1 took away my rigidity, my fatigue, my bradykinesia and reduced my tremor. Well worth the £6 a year it costs me!

[Dap1948 in reply to John_morris71]

You’re a hard task master. I’m sure you know there is no one right dose that fits all. The book does address quite thoroughly how to find the right dose and many of the pitfalls not to fall into on the way. I think if 1g works for you at the moment then that is the right dose. However the book would give you a better understanding of the protocol and what B1 does and stories from 30 of the people who use it.

[John_morris71 in reply to Dap1948]

Not sure if I am a task master (my family members also sometimes suggest that I am very strict ). But I stick to getting the day to day activities done on time and make sure my mother gets her medicines/supplements (on time) along with the physiotherapy and walking too. It took me almost a year to make her walk again and I do not want her to go back to that mode - not if I can prevent it. So I am with her 24x7 - sleeping by her side, eating with her, watching TV with her (what she likes to watch), etc. Basically my life revolves around her.

I am aware that one dose does not fit all. Also, I will read your book - no problem. For now, my mother is doing ok with 1 gm of B1.

Also, am glad that you are doing great and sincere wishes for good health.

[Dap1948 in reply to John_morris71]

What a caring son you are. She’s lucky to have you.

[John_morris71 in reply to Dap1948]

I look at it first and foremost as my duty, more than anything else. Compared to what she has done for me, it is nothing. She has carried me in her womb for 9 months. Being a mother is hard, but special. Nothing against the dads though.

[marimar378 in reply to John_morris71]

You are a good man. The dedication is wonderful. I hope you get a break ever so often.

[chartist in reply to John_morris71]

John,

If you haven't already tried Vinpocetine, you might want to put that on your list to research. I wrote a little about it here:

healthunlocked.com/cure-par...

And here:

healthunlocked.com/cure-par...

Art

[John_morris71 in reply to chartist]

Thanks for the info. Will do

[Basilico in reply to park_bear]

Excuse, but don't you think it can be taken by doing a blood test for TMAO every three/four months?

[park_bear in reply to Basilico]

Yes, you could do that.

[Basilico in reply to park_bear]

OK, thanks.

[Feargaire in reply to John_morris71]

Your mention of TMAO brought to mind a study some years back regarding the gut microbiome and it's impact on the production of TMAO in meat eaters.

It noted that a certain strain was present in various indigenous peoples of South America which belped mitigate TMAO production. Interestingly enough, the same strain was discovered in the gut microbiome of the Irish travelling community via a study on cancer rates amongst meat eaters in Ireland,

This might be of interest

pubmed.ncbi.nlm.nih.gov/316...

[Divii in reply to John_morris71]

how’s your mum doing now?

[John_morris71 in reply to Divii]

She is doing OK. Every day is a blessing. Making her walk inside the house as winter has set in.

[Divii in reply to John_morris71]

best wishes to you all!

[Zella23]

Happy Birthday to your mum! My husband doesn’t take the above supplements so I can’t advise on that but keeps going with the Cinnamon at breakfast. Taken it for a year or so. He also has B1 thiamine.

He has just recently logged on to Brain HQ and completes their free session daily and finds it good, it was recommended by a couple of people on Marc’s zoom meeting. He also tries lots of word games, wordle which help to keep his brain sharp.

[Divii]

very informative; thanks for sharing. I am thinking of starting Citicoline myself