Preventive treatments to slow substantia nigra damage and Parkinson's disease progression: A critical perspective review

[Bolt_Upright]

Preventive treatments to slow substantia nigra damage and Parkinson's disease progression: A critical perspective review 2020 pubmed.ncbi.nlm.nih.gov/326...

This review considers the crucial roles of mitochondria and immune-inflammatory and oxidative pathways in the pathophysiology of PD. High levels of oxidative stress in the substantia nigra, as well as modifications in glutathione regulation, contribute to mitochondrial dysfunction, with a decline in complex I of the mitochondrial electron transport chain reported in PD patients. Many papers suggest that targeting antioxidative systems is a crucial aspect of preventive and protective therapies, even justifying the utilization of N-acetylcysteine (NAC) supplementation to fortify the protection afforded by intracellular glutathione. Dietary recommended panels including ketogenetic diet, muscular exercise, nutraceutical supplementation including NAC, glutathione, nicotine, caffeine, melatonin, niacin, and butyrate, besides to nonsteroidal anti-inflammatory drugs (NSAIDs), and memantine treatment are important aspects of PD therapy. The integration of neuro-immune, antioxidant, and nutritional approaches to treatment should afford better neuroprotection, including by attenuating neuroinflammation, nitro-oxidative stress, mitochondrial dysfunction, and neurodegenerative processes. Future research should clarify the efficacy, and interactions, of nicotine receptor agonists, gut microbiome-derived butyrate, melatonin, and NSAIDs in the treatment of PD.

[Bolt_Upright]

Hmmm:

- NAC

- glutathione

- nicotine

- caffeine

- melatonin

- niacin

- butyrate

- nonsteroidal anti-inflammatory drugs (NSAIDs)

- memantine: This is an ALZ drug. No on that.

[Bolt_Upright]

Caffeine and Parkinson’s Disease: Multiple Benefits and Emerging Mechanisms 2020

frontiersin.org/articles/10...

And now I go back on caffeine! (after going off and on and off and on and off)

[park_bear in reply to Bolt_Upright]

More here:

Coffee and Parkinson's

healthunlocked.com/cure-par...

[MarionP in reply to Bolt_Upright]

Coffee, not caffeine.

[Godiv in reply to Bolt_Upright]

Is it any form of caffeine? Like in tea or did they just test coffee? I thought they started talking about coffee, then switched to caffeine.

[Smittybear7 in reply to Bolt_Upright]

How about green tea?

[kaypeeoh in reply to Bolt_Upright]

Yes, at the the neuro exam two days ago he STRONGLY suggested I go back on caffeine.

[ddmagee1]

Thanks for this input! Sharing this is very helpful!

[Smittybear7]

Thanks

[Sydney75]

This may be an update to your article. It was published in 2021

Novel Pharmacotherapies in Parkinson’s Disease

ncbi.nlm.nih.gov/labs/pmc/a...

Similar information. Elsevier the publisher of the article below is not open source and I could not seem to purchase it.

Preventive treatments to slow substantia nigra damage and Parkinson’s disease progression: A critical perspective review

Keep on researching!!

[Bolt_Upright in reply to Sydney75]

Thanks for the link to Novel Pharmacotherapies in Parkinson’s Disease. That is new and open and detailed. Lots to read. Thanks!