If you are taking glutathione injections, will you please share your experience?
I’m taking Liposomal Glutathione by Quicksilver which I put under my tongue then swallow twice a day. I am concerned that ingesting it accomplishes nothing.
What about S-Acetyl Glutathione in pill form? I’ve read it works whereas just Glutathione does not but it still seems to me that injections would be most effective?
Glutathione IV is best for quick results, but it would get depleted fast. Why don't you try a much better and sustainable Melatonin, it works as a powerful antioxidant, anti-inflammatory, Melatonin and its metabolites easily cross, as well as repair the BBB, and also restores body's own Glutathione
Look at all the research and information in chartist posts
Jay, thank you for reminding me of Art’s work on this. In my research I bypassed it and needed the reminder. Thank you my friend.
Anytime my friend, we are all in this together.
To answer your title:Descending in order of efficacy IMO:-
1. IV / Injection
2. Liposomal
3. Nasal
4. Sublingual
5. Pills
I tried nebulized glutathione for a while. It did not seem to do anything.
I did the glutathione injections every other day for about 6 months after reading Dr Perlmutters book. This was about 4? yrs ago. I wasn’t very bad off and so I didn’t notice any changes but I was trying to be proactive. In the end, I stopped for several reasons. It made my ears ring loudly and I felt horrible for about 30 min during/after injection. It was expensive at least for me.
And mainly, I had a hard time finding veins after awhile. I dreaded the stab and often my vein would blowup.
My functional dr says I should use the type that is sprayed/squirted up the nose.
Dr Mischley did research on nasal glutathione. She recommends pill form, so I'm assuming nasal isn't worth it.
thecut.com/2015/06/problem-...
There are valid points in the article many of which could also be said for the American FDA food pyramid which is also not scientifically sound and is influenced by corporate interests and profits. It’s easier to target Dr. Perlmutter though than the entirety of the American food industry. There are lies and selfish motives on both ends of the spectrum. Finding the truth is therefore left to us, not an easy task unfortunately.
Upton Sinclair: "It, it is hard to convince a man of the truth when his livelihood depends on a lie".
My husband tried the Quicksilver form and seemed to work for awhile. Later turned to the Glutathione IV which was expensive he was being treated for Lyme disease. Tried the IV when he morphed into PD which at that time lasted only a few days. Not worth the cost (not covered by insurance (integrative medicine usually not covered and/or don't accept insurances of any kind) or the two-hour roundtrip travel time.
Switched to the gel/cream Liposomal Glutathione which works, however, have 2 tubes left - needs an RX from an Integrative doctor (don't accept insurance, all private pay).
Would you please share what the gel cream version is? Silly question but you ingest it I assume or skin absorbs it? When he took the quicksilver, how much did you use?
I’m not sure if it’s doing anything in the immediate sense but maybe I should continue if it helps long term.
Navigating what to do is so exhausting.
Your husband is so lucky you research for him.
Sometimes I do too much research and have to take a breather!
Sorry for not giving the full information - made by Researched Nutritionals, called Tri-Fortify Watermelon Liposomal Glutathione. Natural watermelon flavor. GMO- Free.
Open tube, squeeze and swallow (that's what direction say but we put the creamy liquidish gel (only way I know how to describe) onto a teaspoon.
Tube states its only available through health care professionals. researchednutritionals.com
Cost approximately $75 a tube which is 8 fl oz.
Thank you so much! I will look up this specific product. The gel cream form may be better.
I am also taking quicksilver 10 drops each morning on empty stomach. I don't know if it is the glutathione, the rasagiline or combination of both, but my right arm internal tremor and arm twitching has greatly reduced (for now).
Well that’s good news. Very glad to hear your tremor is reduced! Do you hold the glutathione in your mouth before swallowing? The bottle says to for 30+ seconds. I hold it for a couple minutes but I’m not sure if that is pointless. It sure tastes weird. I’m not generally one to rush in to meds but I have encountered so many people who believe rasagiline is neuro protective that I hope to get on it soon.
Dr. Mischley believes it is and strongly encouraged it. Yes, I swish it around in my mouth for a couple of minutes presumably so the cheeks and other tissue can absorb.
Thank you! I will start swishing in the morning. 😊. And I really appreciate knowing Dr. Mishleys thoughts on Azilect.
CC lemonade, I take the same form as you do, sublingually. I’m not sure it does anything but I have stopped it and I have been feeling kind of worse so maybe it does some thing. But maybe to reassure you I occasionally see (via phone) one of the doctors that works with Dr. Mischley and she had me on the sub lingual quicksilver stuff. So it must be pretty good. But boy it is funny tasting and I was getting a little lazy about timing it before swallowing. So I’m going to start it up again and be a little more careful about it. Here’s the thing about the supplements: I have the worst time telling what works and what doesn’t. I mean you’re also affected by probably what you eat a certain day, whether you exercise or get sunshine or whatever. It is frustrating.☹️
Clarifying my response: 1st sentence refers to rasagiline. 2nd sentence refers to the glutathione 
Thank you! Got it. 👍🏻
When I first researched into increasing glutathione in the body as Dr Mishley suggested on her list of supplements, quite a lot of recommendations were for NAC as this is a precursor in the body to help with the production of glutathione. My husband takes 600 mgs twice a day, it definitely seems to help his coughing which was getting annoying for him.
I also have asthma and noticed a big difference when starting taking it. I could breathe much better. Not sure how much it helps with PD and increasing glutathione in the body, but it is a well established supplement.
Hi Zella,
How did you decide 600mg twice a day? Any reference on dosage? Any composition and brand recommended?
Recommended dosage on the container and from research. I buy off Amazon think they are all similar have bought quite a few different makes. My husband started with them at a few years ago and takes twice a day. I buy 600 mgs. They have a very strong sulphur smell.Funnily enough my brother who is similar to me and gets colds that spread into chest infections told me about it a few years ago when it was in a cold/cough prep mix from a French pharmacy. I started to research about it for using it myself, then found it has lots of research, with mixed results, about helping people with PD so that’s where my interest in it as a supplement began.
Interesting. My one doctor, who is a holistic person in my area that I can physically see, recommended NAC after Covid exposure. She said it definitely helps the lungs or would strengthen or clear them in case I did get Covid. Readying for the storm I guess. Definitely something to it.
I have started NAC 500mg morning empty stomach from 4th May.
Will increase to 500mg twice a day from tomorrow.
I am also taking 1000mg Vit C and Melatonin 10mg 30 mins apart before bed. Started Melatonin April 20, and Vit C May 1st.
To accommodate evening NAC, will take it 30 mins before Dinner and split the 1000mg Vit C tablet in 2 doses, half post lunch along with Butyrate, Vit D3 + K2, and 50 bil. CFU 16 strain probiotic, and half Vit. C 30 mins before Melatonin at bed time along with a Clos. Butyricum containing probiotic.
Any suggestions welcome...
I use “restore gold” it has NAC
I’ve contemplated buying it for months. Do you space out dosage to 4 times a day? Part of my reservation about it has been that I believe NAC is optimum on an empty stomach but having an empty stomach at 4 points throughout the day is a challenge.
Do you take it in an empty stomach?
I take the first 4 with my first supplements with medicinal mushrooms and cocoa. Second dose again with other supplements with food, third with supplements and food, fourth long after food. So about half and half! I’m also not using pharmaceutical C/L just mucuna and increasing my B1
“The first 4” ?? I thought it’s 4 total for the day. (Sorry if I’m being a pest with my questions!) I use lions mane powder. I wonder if that’s what you are using?
I’m not on an pharma meds either.
I have recently increased my B1 as well. I’m at 1.5 grams. It is one of the few things I’m doing where I feel confident it is making a positive impact. Mannitol helps me too. The rest....who knows!
I add a healthy scoop of lions mane yes
Restore is 4x day I’m quite small so I actually take 3
That powder mix looks great. Sun Food is the company I use. I appreciate your help!
I appreciate your tireless approach to this syndrome. Many of my issues are cognitive so I follow you and a few others here WAY more than I ever let on
Many of my issues are cognitive as well. Unfortunately we have that in common. My tireless approach is wearing me out. But I want to leave no stone unturned in protecting my brain. Please reach out to me anytime. 🌸😊
My husband takes 600mgs twice a day. It’s supposed to be better on an empty stomach but this doesn’t always happen!!
I used a nasal glutathione spray but changed to oral 10 pumps per day as per Dr. Mischley's recommendation. Can't say whether it is helpful or not....
Are you doing it morning and evening or all at once? I wonder if that matters. I’m presently doing 5 pumps AM and 5 pumps PM both on an empty stomach aside from tea and supplements.
This looked pretty definitive: Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function
ncbi.nlm.nih.gov/pmc/articl...
The results of this pilot study demonstrate for the first time increased body stores of GSH after oral administration of liposomal GSH humans. Liposomal GSH appeared to be effective at two doses (500 and 1000 mg/d) and effects were seen as early as 1 week. In addition, liposomal GSH had positive effects on several GSH-related parameters including decreases in biomarkers of oxidative stress and enhancements in immune functions. Finally, liposomal GSH was highly tolerated and its administration was not associated with any signs of adverse effects.
But then,,, maybe increasing glutathione does not improve symptoms (but maybe we only need to stop progression?):
Potential use of glutathione as a treatment for Parkinson's disease
Glutathione and Parkinson's disease: Is this the elephant in the room? 2008
Okay, I am ready to get some liposomal glutathione! But what to buy? Reduced? Liquid? Softgels? I need advice please.
I use Quicksilver liposomal glutathione. Comes in a pump. I hold it in my mouth for a long time hoping it absorbs that way? What one is reduced?
I’ve recommended this before but I think you should look in to Citicoline.
Thanks CC. I don't understand the QuickSilver dosage of 100 mg when the paper I read showed 1000 mg was much better than 500 mg for raising glutathione plasma levels.
Is anybody just using the lipasomal capsules?
For Lyme disease the integrative medicine firm recommended Tri-Fortify - here is the website
researchednutritionals.com/...
Thank you! Have you personally used it?
My husband and I are trying to purchase it but can’t. We will need to get it through a doctor I think
Unless I can pester you for a suggestion of how to bypass getting it from a doctor ?
Oh, sorry. They used to sell to public. Why would they stop is the question. When hubby was being treated for Lyme we used to get from the integrative doctors. The place is called Stram Center but I doubt they would sell to anyone who is not a client.
I found this site - same product - costs a little more - read the information (I do not know anything about this website other than the product is the same as from the Researched Nutritionals).
Here is the website but please read for yourself -
Should also mention at one point hubby went for Glutathione injections. Cost about $75.00 for injection. Got a shot once a week for a month then reduced to every other week for a month. He had lots of energy at first then around the 8th or 9th injection he didn't notice much of a change. $$ and an hour drive to doctor's office (integrative medicine - all costs out-of-pocket). Went back t the Trifortify Liposomal Glutathione. researchednutritionals.com/...
After a few months he decided to stop the Glutathione. Mainly because it goes with NAC and he felt taking too many pills/supplements even though he knows the benefits.
Wish the neurologist would make suggestions on supplements. It's either RX or nothing. On our 3rd neurologist - he never heard of the HB1 and I bet he hasn't heard of Mannitol (which is on Michael J Fox website for research).
Thanks for all the detail Linda!
HI. Just came across these posts from a year ago. Has there been any change in your thoughts about glutathione? Liposomal? Using NAC instead? My husband does take NAC but only 500 mg once a day. He seems to be getting worse by the week. He gets lost now when he goes on his walks, his posture is very stooped, he can't get properly dressed. UGH. this is so hard.
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