My wife was first diagnosed about 10 years ago and has been taking Sinemet for about 5 years which has kept her Bradykesia in check and allowed her to live a reasonably normal life.
Of late though she has started to experience random short attacks of involuntary and uncontrollable movements of her body mainly in her feet and legs (dyskinesia) that occur without rhyme or reason at any time of the day and in the evening.
Her Parkinson’s nurse first felt that his might be because her Sinemet medication was beginning to lose its effectiveness or that the attacks might have been around the times she took her dosage.
As a consequence she prescribed Sinemet PR (slow release) before bed time to complement her exiting medication regime and this seems to have reduced, though not eradicated the frequency of when my wife experiences occurrences of dyskinesia
Her nurse is now of the opinion that the dyskinesia is being caused by anxiety/stress and tiredness though my wife is adamant she does not experience this She is quite an active person and is trying to balance activity and relaxation periods during the day and go to bed earlier.
I have noticed though that if she has social interactions (via WhatsApp /Zoom or face to face) with friends or family that she sometimes gets an attack and the last couple of times we have been to do the weekly shop it has occurred.
Does anyone else have similar experiences as my wife and are there drugs you could recommend that have helped you to address anxiety that could be added to her medication regime which is as follows.
Sinemet Plus 25mg/100mg 56 tablets to be taken daily at 7.00am
Sinemet Plus 12.5/50mg 280 tablets to be taken 4 times a day (11.00am, 13.30pm, 16.30pm, 19.30pm)
Razagaline 1mg 56 tablets to be taken daily
Spiroco 8mg 56 tablets to be taken daily
Cocareldopa 12.5mg/50mg 280 tablets to be taken 4 times a day (11.00am, 13.30pm, 16.30pm, 19.30pm)
Half Sinemet CR 25mg/100mg 60 tablets to be taken at 22.00