Would love to hear this communities views... - Cure Parkinson's

Cure Parkinson's

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Would love to hear this communities views on Zhittya Genesis Medicine and Dr. Jacobs. This group touts angiogenesis as the possible “cure”?

PalmSprings profile image
25 Replies

There are so many thoughtful and intelligent people on this forum. I just figured many of you have been approached by this company. I guess I am waiting with bated breath for one of these companies like Telocyte, Aspen, etc. to cure us.

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PalmSprings profile image
PalmSprings
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25 Replies
MBAnderson profile image
MBAnderson

I don't know much about it, except they're conducting their trials in Mexico, which should be a concern as to why they're not being conducted in the US.

PalmSprings profile image
PalmSprings in reply to MBAnderson

Yes, this was exactly my thought as well.

MarionP profile image
MarionP

Growing blood vessels? What's the rationale?

PalmSprings profile image
PalmSprings in reply to MarionP

Good question, “Let me give you a summary of this research paper: The human brain of an 80-year old is as vibrant as an 18-year old, in terms of containing neuro-stem cells, neurons and the ability to regenerate all areas of the brain. The problem is that over time the blood flow in the brain is obstructed and those neuro-stem cells, neurons and their supporting cells received less and less blood flow, leading to aging of the brain in healthy adults. This is what we also believe is the initiating event in neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease.

Who would have guessed that aging of the brain is a vascular disease, besides me?“

And that is their premise?

condor39 profile image
condor39

I am not sure why you are asking our views when the studies are not complete ?

PalmSprings profile image
PalmSprings in reply to condor39

Maybe I should have been more clear. I am also wondering if any of you have received the material by email about this company? My neurologist said the HDT was not double blind studied and so when I asked about it a week ago, he literally blew it off. And are we not some of us opting to be in studies or human trials to test hypotheses that have been shown to have possibilities in mice studies? I am also asking about angiogenesis. Does it have legs or is angiogenesis just snake oil?

MBAnderson profile image
MBAnderson in reply to PalmSprings

The CEO says they're trialing it in Mexico to speed approval. I doubt the US allows companies to market pharmaceuticals in this country that are approved by the equivalent of the Mexican FDA, otherwise everyone would do it, so even if they get Mexican FDA approval, it can't be legally sold in this country.

Also, if I remember correctly and I'm not sure that I do, don't they claim that growing new blood vessels is the cure for many diseases?

Thirdly, traveling round trip to Mexico during a pandemic doesn't sound too appetizing to me.

I would take a pass, myself.

PalmSprings profile image
PalmSprings in reply to MBAnderson

I have no plans to be part of this trial. My sister tried to get me in Dr Jeanne Loring’s stem cell trial but I prefer to observe a bit longer. I am trying to glean information about all treatments before jumping. So far what I know the only thing that has truly worked for me is c/l and exercise. And c/l only gives symptom relief. I have steadily progressed, six years since diagnosis. I am not expecting any miracles really. I am enjoying the academic study of the disease, treatment and the elusive cure.

MBAnderson profile image
MBAnderson in reply to PalmSprings

Ms. Springs, :) I would be leery of anyone who says they can cure Parkinson's. If that were true, every major Parkinson's organization would be publicizing it, as would most scientific journals. Wolf Blitzer would announce it.

To me, the real tipoff is the claim that their therapy can cure several diseases.

I believe blood profusion is good for us, but a cure??? e-e-e-e-h-h-h, not so much.

Despe profile image
Despe in reply to PalmSprings

Dr. Costantini submitted paperwork required for B1 trials to MJFF, but was disapproved.

PalmSprings profile image
PalmSprings in reply to Despe

I wonder why? I would be interested in the rationale behind the rejection.

Despe profile image
Despe in reply to PalmSprings

Reason, different PwP need different B1 dosage, something like that. Art probably can write more about the reason it was rejected.

MarionP profile image
MarionP

Growing new blood vessels is a two sided coin, which explains some of the literature and nomenclature that talks about that other side of the coin, though the references are not exactly, what's the word, 'prominent'...(one must dig just the tiniest bit)...which is how growing new blood supply also can help grow new cancers...which is what their hoped-to-be (I guess) not-so-attention-getting but to me somewhat curious appearance of the word "oncogenesis" is about, which word literally means "cancer growth," and why would they put a mention of how so far they don't see that the process has yet promoted growth of cancer, specific single type of cancer they were were apparently watching for...thus that is their way of referring to what their so far somewhat small flashlight beam would hope is just a small potential side effect, 'nothing to worry for really or we would of course have said more' sentiment.... Concerning though when you mention subtlety with unusual high specifity, just why that particularly specific subject is singled out for energy to look for to rule out...kind of like mentioning the specific risk of, say, the risk of finding a tuna sandwich..."no tuna sandwiches occurred in the studies thus far...". If they put energy into that, begs a question then about why they weren't also concerned about finding a peanut butter sandwich, or a taco... No need to look for peanut butter, so what justified the resources to rule out the tuna sandwich, why no need to do likewise for a ham sandwich or a burrito or kebab, etc.? Just tunafish. I know, let's first try it on some Mexicans, you know, just in case.

MBAnderson profile image
MBAnderson in reply to MarionP

ha

Isthistheone profile image
Isthistheone

Hi Palm Springs. I've been following this company for three years or so. They are very enthusiastic about their product, and what they believe is the root cause of Parkinson's disease, namely insufficient blood flow in the dopamine production area of the brain. I'm not a medical professional, just a PWP. Their approach seems reasonable, just my opinion. ZHITTYA filed an application with the US FDA for a Phase 1 trial during early/mid 2019 I believe. The FDA required additional information then Covid-19 hit. The company realized then no mater what the future held, they were small potatoes. So they went south to Mexico. The Mexican FDA approved ZHITTYA GENESIS MEDICINE'S investigational compound, FGF-1, for a Phase 1 trial.

Parkinson's News Today, Feb 18 2020 has an excellent article on this. Google ZHITTYA White Paper.

Just my opinion, we are going to hear a lot more of ZHITTYA in the future.

The company released another White Paper dated Jun 17 2020, entitled Covid-19 Lung Damage - Can inhaled FGF-1 be a Viable Treatment?

ZHITTYA is planning to file a Phase 1 clinical trial for COVID-19 lung damage in Mexico as well.

No one has cracked the code yet. Said this many times before - there are so many brilliant and dedicated people worldwide on a 24/7 schedule to find a cure. Have faith, take care, be safe and God bless.

PalmSprings profile image
PalmSprings in reply to Isthistheone

Interesting, that they are dipping into the Covid19 area. Is this follow the money?

MBAnderson profile image
MBAnderson in reply to Isthistheone

Hi Jim, long time no hear. Are you getting tempted to go to Mexico?

Isthistheone profile image
Isthistheone in reply to MBAnderson

Not yet Marc, more info req. They have piqued my interest. Every day we are getting closer. There are many motivating factors in the race to find a cure. At the top of the list is financial reward. My radar is always tuned to that frequency. Trust everyone in the game, but always cut the deck (The Great Communicator).

Stay well.

beehive23 profile image
beehive23

i dont look for a cure..........cheers.

PalmSprings profile image
PalmSprings in reply to beehive23

I really understand the idea behind making the best of the card you’ve been dealt. I am not expecting a cure in my lifetime. I am trying to make everyday count and I am adapting to my new body as time passes, so I think I get what you are saying. Cheers!

beehive23 profile image
beehive23

im just tired is all...............like permanently not just at this moment.....Cheers!

PalmSprings profile image
PalmSprings in reply to beehive23

I hear you....cheers!

chartist profile image
chartist

PalmSprings,

I think it is simpler, safer and easier to use Vinpocetine for the purpose of improving brain blood flow and increasing brain oxygenation as well as improving memory and improve glucose uptake by brain cells which improves mental energy. It is readily available over the counter without prescription and is inexpensive with an established safety profile.

pubmed.ncbi.nlm.nih.gov/177...

As MarionP pointed out above, increasing angiogenesis may come with added potential for cancer potentiating as angiogenesis is one method that cancer uses to proliferate and metastasize. Some people try to control cancer proliferation and metastasis using known antiangiogenic supplements such as curcumin and EGCG from tea.

Another consideration is that PD is an age related disease, meaning that age is a prominent factor for increasing your chances for PD. Many forms of cancer are also considered an age related disease. In autopsy, many elderly people present with undiagnosed cancer and it is a legitimate possibility that increasing angiogenesis in a patient with undiagnosed cancer could feed the cancer. Cancer cells generally multiply much faster than normal cells and in order to do this, they actually create new blood vessels via chemical signaling to get more blood so that tumors can grow and multiply. This is angiogenesis in action. The problem with angiogenesis is that it takes time and a patient being treated to increase angiogenesis to improve brain function may also be helping an undiagnosed cancer to grow and metastasize and then months later are diagnosed with cancer and the patient may never even realize that they were helping the cancer to grow by essentially giving it more blood.

Art

PalmSprings profile image
PalmSprings in reply to chartist

Thank you for your thoughtful reply. I really appreciate the information and knowledge that comes from people on this forum.

Zhittya profile image
Zhittya

This is Daniel Montano-CEO of Zhittya Genesis Medicine. We have obtained regulatory approval in Mexico for the First in Human clinical trial to treat Parkinson's Disease using FGF-1. We have a similar Investigative New Drug Application (IND) at the US FDA. The US FDA wants additional animal data. The Mexican regulatory authorities accepted our animal data to grant us approval to proceed. Monkeys given Parkinson's Disease developed all the classic movement symptoms of a human affected with the disease. Half of the monkeys were given FGF-1 and started to return to normal, while the other group worsened materially. The Proof of concept trial in Mexico is to identify two items. One is FGF-1 safe to administrate into the human brain? Two is there any benefit to the patients? If we fail on step One, there is no need to spend $5 million dollars proving it is unsafe in the United States under the FDA. If it is not safe all stops. If it is safe as we hope, then the question is can FGF-1 reverse Parkinson's Disease in humans, as it did in monkeys? If you go to YouTube and Search Zhittya, you will find our webinar presentation on why we believe FGF-1 can treat Parkinson's Disease. Are we correct? We do not know. We believe we have great medical scientific evidence that FGF-1 can reverse Parkinson's Disease. How strong is our belief? I have invested over $26 million USD, so at least you know I believe. All we ask of the Parkinson's Community is to watch our medical scientific data. We have nothing to sell and no services to offer. We should know within 12 months if it is safe in the brains of Parkinson's suffers. I also hope we see confirming evidence it has similar improvements to that which was in the monkeys. Who knows maybe our 23 years of hard work and the $140 million we have expended was not a "Fool's Errant?" Dan Montano

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