I have lived on a lake for most of the past 20 years, including now. This intrigues me.
Parkinson's disease linked to gene target... - Cure Parkinson's
Parkinson's disease linked to gene targeted by blue-green algae toxin
Written by
jimcaster
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It's always helpful to find new possible contributions to this disease, and tempting to read too much into it. I have never lived near a lake. Presumably your wife and a chunk of neighbors have also lived there without getting PD
I understand, but I think we have only scratched the surface on the link between environmental factors and genetics. Maybe millions of people get exposed to the same toxin, but only a tiny fraction get PD because of the toxins affect on their unique genetic makeup. I think there's a lot more than just LRRK2 and GBA to be concerned about, but we haven't discovered it yet. In the meantime, it gives me something to think about. 😊
It is a weak result:
"Our findings, although not directly implicating BMAA in risk of PD...More research is warranted to determine whether dietary exposure to BMAA results in hypermethylation of cg06690548, if altered methylation at this CpG also occurs in the substantia nigra, and whether these methylation changes are associated with an increase in oxidative stress in these cells via downregulation of system Xc-....
The SMR results imply that the association of cg06690548 with PD is not owing to genetic factors and so may reflect a PD-related environmental exposure"
BMAA toxin of cyanobacteria has been implicated with ALS, Alzheimer's, Parkinson's, etc. for a while now. The key to neurological morbidity is this, no matter what the actual source amongst toxin/metal/stress/nutrition, etc.
"Researchers predict this will lead to HIGHER OXIDATIVE STRESS levels in nerve cells associated with Parkinson's disease, which can lead to cell death."
Check out the video on the below link for additional intriguing link between BMAA and marine food web.
The related film "Toxic Puzzle - Hunt for the Hidden Killer" may also be worth checking out, and it highlight the importance of the amino acid l-serine.
Why? It's vitally important for the CBS enzyme of the transsulfuration pathway to utilize serine, b6 and Fe for adequate detoxification through glutathione.
We lived on a man made lake in the late 70's for about 7 years. It was filled with rain water and was murky. My husband with PD swam it often. I never did, even once.
I grew up on a lake for the first 13 years of my life in the 70's and 80's. The house's sewage systems were so bad that the lake would clog with seaweed many summers. I am guessing there was a lot of algae too. I was in the lake all the time.
