I am rigidity- dominant PD ; My personal experience!

[Kia17]

I am rigidity -dominant PD and like other PwPD my main issues arise when imbalances between Acetylcholine and Dopamine and other neurotransmitters occur. I think we are either Dopamine- dominant or Acetylcholine- dominant( my case) PD.

📍📍Note: The DaTSCAN image doesn't belong to me and that's for a healthy non-PD individual that I found on the internet.

I managed to balance these neurotransmitters and reduced my symptoms with the following interventions:

💢 My main symptoms;

•Dystonia (low degree)

•Bradykinesia (low degree)

•Stiffness (low degree)

✅I am good with:

•B1 Thiamine

•B12

•B2

• Magnesium

•Higher methylation

•Vitamin D3/K2

• Mannitol powder

•Foods with less or no Choline

•Alkaline foods

•High-fat foods and vegetables that are healthy and nutritious

•Hazelnut/Macadamia/Almonds

• Fish (Salmon)

•Lamb meat

⛔️I am NOT good with:

•Choline

•Calcium

•Methionine

•Omega-3 fatty acids

•Vitamin C

•Zinc

•Anything increases Acetylcholine in CNS or PNS

•Vitamin B6

•Folic Acid (Folate)

•Niacinamide (B3)

•Acidic foods

• Dairy products

•Stress

•Low methylation

•Vinpocetine

•Celery seed extracts

•Lithium Orotate

•Fish (except salmon)

•Beef

•Sugar/ Carbohydrates

•Gluten

💥Interventions:

•Taking foods and supplements that I am good with as above.

•Avoiding foods and supplements I am not good with as above

•Intermittent Fasting

• LCHF diet

•MTHFR gene test (pending).

•Fast walk

•Cycling

•Yoga/ Meditation

•Five Element Yoga

•Kundalini Yoga - Pranayama

•I am looking for to find a way either exercise or supplement to manage Acetylcholine balance with other neurotransmitters.

•Before meditation,I look at the image uploaded for this post.

•📍📍The DaTSCAN image doesn't belong to me and that's for a healthy non-PD individual that I found on the internet.

[Gioc]

If mitochondrial dysfunction theory is correct you don't have a set-up in this, it might be important to have a handling aid to the mitochondria, or am I wrong?

[Kia17 in reply to Gioc]

Gio

I think Methylation balance should be the core focus to overcome the mitochondrial dysfunction.

[Gioc in reply to Kia17]

Ok thank you, I think I have to study this subject better, I still have not understood it well with all the related to the PD.

[Parkie-]

Thank you for posting this precious information.

[Kia17 in reply to Parkie-]

You’re welcome

[ConnieD]

Hi Kia! I am rigidity dominant (non tremor) too, do you think most non tremor dominant PWP are more likely Acetylcholine dominant ? Thank you, Connie

[Kia17 in reply to ConnieD]

Hi Connie

Acetylcholine is an excitatory neurotransmitter (generats a signal called action potential in the receiving neuron) while Dopamine and GABA are inhibitory neurotransmitters. I am convinced that my problem isnot with Dopamine production but with misfiring or high concentration of Acetylcholine in which the outcome is ACh overrides the Dopamine and symptoms present as stifness,Bradykinesia or dystonia.

[ConnieD in reply to Kia17]

Thank you Kia very interesting since I have the same symptoms as well as one copy of the mthfr gene. Great information! Connie 😊

[Kia17 in reply to ConnieD]

You’re welcome Connie.

[akgirlsrock in reply to Kia17]

If no tremor does that mean your dopamine isn't as low as some with tremor and rigidity on one side as I am in left leg. I only notice when coming off of cardopa/levadopa I get Dyskinesia and my leg gets stiff, and when iff of pills it wasn't stiff. I had ice cream small scoop which I usually don't and Ate a burger plain with broccoli at 4:30 and 9:41 and I have Dystonia, in feet/calves I don't know if it's low dopamine or choline. I'm shaking to my Er night pill which takes a while to work and I just took one 25/100 cardopa/levadopa to help dopamine get in my system faster will see. Sorry about all the info, I'm trying so hard to figure how yo not get Dystonia. Thank you, for all you info, Maria

[akgirlsrock in reply to Kia17]

Are you taking meds?

[KERRINGTON]

Thank you for all this new information .What does one do if they are tremor dominant, with accompanying rigidity ?

[Kia17 in reply to KERRINGTON]

All is about balance between neurotransmitters either with food we eat, exercise, medications, Meditation , supplements and lifestyle changes.

[KERRINGTON]

As I research, and digest what you shared, I just determined that I am extremely low in Acetycholine. As it happens I just recently started taking supplements to feed my mitochondria which are also helpful to raising Acetylcholine. I have a lot more variables to checkout, but I'm hoping to report some progress a month from now. Thanks again !

[Kia17 in reply to KERRINGTON]

Best wishes

[reedboat2 in reply to KERRINGTON]

May I ask how did you determine that you are acetylcholine deficient? Thanks- John g

[KERRINGTON in reply to reedboat2]

I have searched the web for symptoms of high and low dopamine, as well as symptoms of high/low acetycholine levels ever since I read Kia's first post on this. Not scientific, but I'm hopeful.

[Kia17 in reply to reedboat2]

I amnot Acetylcholine deficient but dominant. I noticed from the symptoms.

[Jumex2017]

How does one know whether one is acetylcholine or dopamine dominant?

[KERRINGTON in reply to Jumex2017]

Hi ! Please see my response to reed boat2

[Kia17 in reply to Jumex2017]

From the disease presentation I guess.

[reedboat2 in reply to Kia17]

I just took the online Braverman Personality Test which showed a history of being Dopamine Dominant. It seems however that now, in a later stage in life, and dealing with PD, that trend may be shifting. As you say, it’s all about balance. 😀 JG

[Lana666]

Hi Kia,

Thank you for your research. Interesting. I am same type. But I’ve been taking number of supplements from your NO list. And some felt good. I guess, I will try to check literature as well and may be reproduce your regimen, and see if any change comes out of it.

[Kia17 in reply to Lana666]

Hi Lana

Thanks for sharing.

[akgirlsrock]

Where do get tested for methylation?

[Kia17 in reply to akgirlsrock]

My symptoms and trials with foods and supplements.

[Kia17 in reply to akgirlsrock]

23and me or AncestoryDNA.

[condor39]

Wow, it is hard to believe all that you are doing. I suggest that you are trying too hard.

I have the same symptoms, but fairly well controlled with Madopar, with NO special diet,

NO supplements, NO special exercise.

I had to increase the Madopar (actually Prolopa, the Canadian version ) to 25/100, three capsules four times a day, which is a high dose, but no side effects.. I increased to this dose very slowly.

But hear in mind, we are all different, and what suits one may not help a mother

[Kia17]

I highly recommend reading this article:

Parkinson's Disease and Neurodegeneration: GABA-Collapse Hypothesis

frontiersin.org/articles/10...

[Kia17]

Does GABA Cross The Blood Brain Barrier And Does It Matter?

youtube.com/watch?v=YhsTCo5...(Not working as expected?)

[AmyLindy]

@Kia I’m envious of ur precision- who did your work up? And Are you a clinician or scientist 👨‍🔬?

[Kia17]

Hi AmyLindy

Please don’t be.I am neither a scientist nor a clinician 😊but like dig deep into things that have affected our lives.

[Gioc in reply to Kia17]

Kia, I really appreciate your posts because they are very communicative, but they have a peculiarity: in a sea of ​​information where each drop is the same as another, your posts give us the most important information to live with the PD, as summarized in your profile. It is short but I know how much research and personal experimentation is behind it. Thanks Kia for sharing it. A person is of value to the extent that he is helpful to others, you have been for me for a long time. Gio

[Kia17 in reply to Gioc]

Thank you Gio. You have also shared good information about the PD since I have been in this forum and I am really greateful for having you here.Best wishes, Kia

[Gioc in reply to Kia17]

😀

[akgirlsrock]

Is anyone supplementing with Gaba. Also I read if taking vit D you must take vit K7 for calcium to deposit in bones. I've used k7 from Natto source that is fermented which is best, which isn't a hormone disruptor, I think. I wonder if getting tested for calcium would tell us anything. Thoughts anyone. Thank you, Maria

[Kia17 in reply to akgirlsrock]

Maria

I have been taking GABA supplement (not pharmaceutical grade) for a month with a very calming and relaxing effects as it buffers Acetylcholine effects , I geuss.

Interms of taking VitD with K2 ; there are different opinions some says it’s necessary some say taking Vitamin K2 with D3 is useless but I take D3 and K2 myself. Hope these help.

[munchybunch in reply to Kia17]

Hi Kia can I ask pls what brand and dosage you use. My husband too is rigidity dominant so I’m thinking he probs should be on what you re on! Thanks

[Kia17]

Hi

I stopped taking GABA after a couple of months since it exacerbated my dystonia.Hope this helps.

[aspergerian]

Excellent summary of your personal lessons. Anecdotal can be very informative. Thank you!

[Kia17]

Thank you

[simonasays]

this post is old - but wondering if this theory also can be linked to why some people just dont respond to their LD/CD - because of Acetylcholine. also wondering whether your MTHFR gene test turned out to be +

[Kia17 in reply to simonasays]

I don’t think that’s the reason if someone doesn’t respond to Ld/Cd.

Yes, I have Homozygous MTHFR snips.

[simonasays in reply to Kia17]

Keep coming back to this post and thinking it over. Thank you for this. In terms of MTHFR - do you supplement with methylated b12 ? iron been low in the past? Also, did you ever go back to GABA? possibly try to decrease dosage? maybe it left your CD/LD dose too high? curious your thoughts as to why it would be responsible for inc. dystonia.

[Kia17 in reply to simonasays]

Still I am taking methylated b9 and b12 . No GABA.My Sinemet intake dosage still is; 6.25/25 mg 3 times a day.

I think GABA supplements disturbs Glutamate balance and can contribute to worsening of progression and causing dystonia.

[Divii]

Once I get up in the morning, my legs are like jelly n I'm not able to walk , dopamine takes a longtime to relieve symptoms

[lionessroar]

I think I am also acetylcholine dominant. I don't understand exactly how B1 affects acetylcholine but I wanted to ask what form of thiamine you use and what dosage.