Altered Immune Cells Beat Leukemia

This relates to Leukaemia in children, but an interesting development none the less.

From The New York Times. 9 December 2012 [online] Available at: nytimes.com/2012/12/10/heal... [Accessed 14 December 2012].

[HAIRBEAR_UK Founder Admin]

Yes Talesin this is very interesting and exciting and is exciting the clinicians. I am hoping there is more from this year's ASH?

This is a video interview with professor John Gribben from last year;s ASH discussing this therapy and the results from it's trial in a few CLL patients. there were a few adjustments that they were hoping to design into the treatment as fail safes to turn off the treatment and make it CLL cell specific.

Chimeric Antigen Receptors (CAR) From ASH 2011 ,Has anyone information that summarises the latest developments with this particular therapy discussed this year??

youtube.com/watch?v=pMHvW_b...(Not working as expected?)

Nick

[Hidden]

That was quick Hairbear;

OMG The Hairbear Bunch, I used to love that when I was at school (early-mid 70s?).

Thanks for the comment, very interesting.

[HAIRBEAR_UK Founder Admin]

We crossed with our posts. I had just forwarded another broadcast from this years ASH and CART is included in the discussion. I happened to have the CART broadcast to hand. there are a few new exciting approaches to CLL treatment. I am interested in this years developments with this in CLL

Yes the Hairbear bunch was a daily ritual as I returned from school every day. Cartoons, love them

nick

[Cllcanada Top Poster CURE Hero]

Here is a recent overview...CART 19

elsevierconnect.com/penn-an...

Look for a new target, ROR1, similar technology at MDAnderson, trial next year

[HAIRBEAR_UK Founder Admin]

Thanks Chris great article.

Here's a link to an interesting video broadcast explaining ROR1, this outlines what is being developed and investigated scientific stuff but it is presented in an understandable manner (if you are interested in this kind of thing). I imagine this work may have progressed a little further, any news yet Chris?

patientpower.info/video/att...

For general info; the library of brief video interviews available on the patient power website on a variety of topics from ask the doctor Q&A, interviews with patient advocates, advice from consultants to progress with research etc. ( :

Chronic Lymphocytic Leukemia (CLL) Videos:

patientpower.info/health-to...

[Hidden]

Scared. Just diagnosed with a count of 14.5. Have a 14 year old and 8 year old. Any advice. X

[Hidden in reply to Hidden]

Hello Fiona;

Congratulations on being diagnosed so very early.

Mine was low at 31.

There are many knowledgeable people here. People having lived with CLL for decades.

Treatments have good success rates and there are some amazing new treatments not far away from being generally available.

I have had CLL for at least three years and I have no symptoms.

I cannot promise everything will be fine, but your chances are very good and significant improvements are being made right now.

Follow the links in the replies, see what is happening

There are brave people here, it's surprisingly infectious.

The first thing you must decide is how much do you want to know. Especially while still coming to terms with your feelings. Take it from there. Ask questions but make people understand what you are open to hearing. See how things go. There's no rush.

[Cllcanada Top Poster CURE Hero]

Patients interested in the small CART19 trial may access more information here.

Abramson Cancer Center of the University of Pennsylvania:

penncancer.org/Tcelltherapy/

and

clinicaltrials.gov/ct2/show...

Note this is a trial for heavily pre-treated patients with progressive disease.

~chris