My twin sister has CLL and we finally got the results today from Boston Heart Lab’s semi quantitative IgG assay against the spike protein (code 648) and sadly the result was .04 and the test’s description says anything over .08 is positive for seroconversion. However, after reading about the test’s criteria today, we learned that we may have drawn the blood too soon. It recommends >3 weeks post first or second shot for accuracy and we did it the second week post first vaccine. As soon as we get the second test results, I’ll post again. I’m trying to get a T cell antibody test as well. I’ll read AussieNells post to see if there are any tests available for T cell antibodies to the Covid vaccines.
Some background - My twin sister who is 53 had a CLL complication of AIHA several months ago (was on W&W for 5 years) and had to start prednisone and Rituximab with Ibrutinib during the heat of the pandemic in Los Angeles. Her immune system was severely compromised by her CLL, ibrutinib, prednisone and Rituximab, all which lower your immune system’s ability to fight infection. I read that Rituximab (anti CD20 monoclonal) can take 6-12 months for your immune system to recover after your final infusion and her last infusion of Rituximab was Oct 1, 2020 so she was just shy of 6 months when she got her first Pfizer shot. Our hope was that she had enough T cell recovery to mount a response to the vaccine; specifically the CD4 and CD8 T cells (infection fighters) which can be reduced from Rituximab and are key to survival from Covid.
We read that while on ibrutinib seroconversion from vaccines can be extremely low. “Seroconversion after the seasonal influenza vaccine in patients receiving ibrutinib has been reported to be as low as 7% in 1 study evaluating the standard-dose vaccine and 26% in another in which a proportion of patients received a higher dose. Jan 14, 2021”
Apologies for the lengthy post.
Stay safe and healthy!