Umbralisib & Ibrutinib Clinical Trial

[Yuck]

Please message me if you are also in this very small U.S. trial run out of Dana Farber in Boston, but at others sites too.

Thank you!

~ Yuck

[AussieNeil Administrator]

Hi Yuck,

Did you see this?

Dr. Davids on Remaining Questions With Umbralisib/Ibrutinib in CLL and MCL

"The key takeaway from the longer-term follow-up on a phase 1/1b study (NCT02268851) examining the safety and efficacy of umbralisib in combination with ibrutinib in patients with CLL and MCL is that the initial results are holding up for the patients with CLL, with durable responses observed, says Davids. Moreover, higher rates of complete remission (CR) were reported with ibrutinib monotherapy, which was not expected.

There is currently some debate in the field right now on whether CRs are indicative of better outcomes for patients who are receiving a continuous therapy. These data are supportive of the possibility that achieving these deep reemissions can help sustain remissions for longer, as can be seen with the very impressive progression-free survival and overall survival data, according to Davids."

onclive.com/view/dr-davids-...

Neil

[Yuck]

Didn’t catch it. Many thanks!

As I have said before, you rock!

[Yuck]

Hi Neil,

YouTube shows the clip of Dr. Davids of Dana Farber, Boston MA speaking about the research results to date in the study he has been running for more than 4 years using Umbralisib (a new Pi3K with fewer side effects than Idelalisib and Duvelisib) in combination with Ibrutinib.

OncLive has removed the video clip and the transcript is “wrong.”

It reverses Dr. Davids’s words!

Here is the YouTube link

which some people may find encouraging.

Hope so! And Thanks again!

youtu.be/l1vcUoCmNFY(Not working as expected?)

~Yuck