Ibrutinib and Orange Juice

[Traudel]

Please if I could ask for assistance again:

I am seeing different opinion in consuming Orange Juice.

I'm taking 420 IB in the AM with 1 glass freely squeezed orange/or blood orange juice, mostly 3 oranges, "N O T SEVILLE " NOR Grapefruit juice.

Could this interact with IB?

Appreciate any answer,

Happy Valentine,

Traudel

[MsLockYourPosts Passed Volunteer]

There is no problem with orange juice that anyone has reported. If you find that your stomach is a bit upset you might want to take something else with the pills, but that wouldn't mean needing to give up your orange juice. I'm not currently in treatment, but I have never been able to drink coffee and orange juice together because of the acidity. I haven't given up either - just space them out.

[PlanetaryKim]

actually, I have read that blood oranges (the ones that are red inside, from australia) are a problem for us. they inhibit cyp 3a4 in same way as grapefruit and seville oranges do.

[PlanetaryKim in reply to PlanetaryKim]

I can't find a source for this now. So I am not sure. I have absolutely read it somewhere in the past so have avoided blood oranges for this reason while on ibrutinib. but cannot find it now.

[june65 in reply to PlanetaryKim]

I’ve also seen somewhere not to have blood oranges as well as grapefruit and Seville oranges, star fruit and I think pomegranate

[Traudel in reply to june65]

Hello again,

I'm in total agreement with Grapefruit and all others but still questioning Blood Oranges. Will bring this forward to my pharmacist, who patiently explained what not to take, but Blood Oranges were not in question at the time.

Thank you to everyone for posting AND INFORMING,

Best

Traudel

[mrsjsmith in reply to Traudel]

Traudel,

This has been mentioned many times here, but let me quote from my Janssen paperwork ‘ Do not take Imbruvica with grapefruit or Seville oranges, this includes eating them, drinking the juice or taking a supplement that might contain them. This is because it can increase the amount of Imbruvica in your blood.

Colette

[Traudel in reply to mrsjsmith]

Thank you Colette.

I understand, the question was ....... "BLOOD ORANGES?"

We understand all others.

I take juice 3 blood Oranges every Morning to take IB with it.

In addition I use Hemp Hearts, Flaxseed, Black Sesame Seed and Chia Seeds.

Kim was the only member, who had read about Blood Oranges not to use.

Of course I am now concerned and will have to change to Navel Oranges.

Best,

Traudel

[mrsjsmith in reply to Traudel]

Traudel you shouldn’t be taking Flaxseeds either. On the list of things that may increase a risk of bleeding.

Colette

[Traudel in reply to mrsjsmith]

Thank you Colette, appreciate .........

[country76 in reply to Traudel]

I thought we could not take flaxseed?

[MsLockYourPosts Passed Volunteer in reply to Traudel]

DescriptionCitrus × sinensis, also known as the Citrus sinensis, includes the commonly cultivated sweet oranges, including blood oranges and navel oranges. Wikipedia

Scientific name: Citrus X sinensis

Family: Rutaceae

Kingdom: Plantae

Order: Sapindales

Rank: Species

Higher classification: Citrus

I have never seen any warnings about blood oranges. I would be interested in any reliable source that shows otherwise.

Edit - Found this. Researchgate has other grapefruit related info. This one mentions blood oranges, specifically, as being OK, and that some limes aren't.

(PDF) Drug Interactions of Grapefruit and Other Citrus_What Have We Learned? - ResearchGate

[starsafta]

Personally, I think medications are best taken with plain water to avoid any reactions. I learned the hard way not to take Imbruvica with warm/hot tea, as the outer shell immediately begins to soften, even before I can swallow. It actually makes it more difficult to swallow because it turns slightly slimy. I'm surprised the literature doesn't mention cold water only.

As for oranges, there is one more to add to the list. A friend has gifted me with a monthly delivery of fresh fruit. The first two months were beautiful pears. This month, I opened the box to a burst of brilliant sunshine, with 14 gorgeous tangelos.

They immediately conjured up a trip I took with my son's family many years ago. After a lot of walking on a warm day on the hills of San Francisco, we stopped at a little store to get a snack. My two young grandsons each got a power bar. I bought a tangelo. As we continued walking, I peeled open the fruit and ate the first tangy, sweet and tart segment, reveling in its deliciousness. My two grandsons asked if they could try it. I wound up getting 2-3 segments, giving the rest to them.

Now I have to be more cautious. Before peeling one from the gift box, I decided to do a little research. To my dismay, I discovered that tangelos are a cross between pomelo, a type of grapefruit, and tangerine. The first pomelo I had was in Israel many years ago, where I ate it right after picking it off a tree. It was delicious.

I gave the box to a neighbor, turning my loss into the joy of making someone else happy.

[Sierrastar]

I love canned mandarin oranges with cream, which I eat about 3 times per week.

Good health, Elizabeth.