Validation of a vitamin D replacement strategy... - CLL Support

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Validation of a vitamin D replacement strategy in vitamin D-insufficient CLL patients...

Cllcanada profile image
CllcanadaTop Poster CURE Hero
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Vitamin D insufficiency has been linked to poor prognosis in patients with malignancy, particularly lymphoid malignancies.

Currently, from the Mayo study..

Patients should be counseled that vitamin D replacement appears to be safe; however, whether it actually alters cancer prognosis remains to be determined.

Letter to the Editor

nature.com/bcj/journal/v7/n...

Thanks Lisa M for this...

~chris

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Cllcanada
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AussieNeil profile image
AussieNeilAdministrator

Appropriately, this important news has been doubly posted:

healthunlocked.com/cllsuppo...

Given vitamin D replacement appears to be safe and a recent global study shows that higher levels protect against colds and flu, we really should find out if our vitamin D serum level is adequate:

healthunlocked.com/cllsuppo...

Neil

Jm954 profile image
Jm954Administrator

Vitamin D deficiency (admin) appears to impairs Rituximab-mediated cellular cytotoxicity and has been associated with poorer outcomes and survival in elderly patients with DLBCL.

See refs:

Vitamin D deficiency impairs rituximab-mediated cellular cytotoxicity and outcome of patients with diffuse large B-cell lymphoma treated with but not without rituximab: ncbi.nlm.nih.gov/pubmed/251...

Vitamin D deficiency may impair rituximab mediated cytotoxicity diffuse large B-cell: managedhealthcareconnect.co...

25-OH-Vitamin-D Deficiency Impairs Rituximab-Mediated Cellular Cytotoxicity and Is Associated With An Inferior Outcome Of Elderly DLBCL Patients Treated With Rituximab: bloodjournal.org/content/12...

I found out I was severely Vit D deficient (level of 7) halfway through my R treatment and had to have 50,000 units for 12 weeks. Although I knew all this information about Vit D and R before my treatment, I didn't take any supplements - I was in a bit of a fog at the time, tired and ill. However, I take them regularly now and some of my cramps have improved.

Perhaps all patients who are planned to have R should have their Vit D levels checked before they start treatment?

AussieNeil profile image
AussieNeilAdministrator in reply to Jm954

Thanks for these references. I've taken the liberty of clarifying that it's a vitamin D deficiency that appears to impact Rituximab-mediated cellular cytotoxicity with DLBCL, though interestingly, I couldn't find a reference to the same effect with CLL. Interestingly drugs.com doesn't report any interaction either.

Neil

Cllcanada profile image
CllcanadaTop Poster CURE Hero in reply to AussieNeil

It would be interesting to see a similar study using Gazyva in CLL since its main kill mechanism is ADCC... which the VitD/Rituxan study appears to involve, atleast in DLBCL...

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