Ibrutinib resistance mutations often arise ear... - CLL Support

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Ibrutinib resistance mutations often arise early, suggesting potential as a cue for alternative therapy

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AussieNeilAdministrator
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Mutations in two genes often occurred months before relapse of chronic lymphocytic leukemia (CLL) treated with ibrutinib (Imbruvica), suggesting potential as a cue for alternative therapy, according to a retrospective review of four clinical trials.

Among patients who had CLL relapse, acquired mutations in BTK and PLCG2 occurred in 85% of cases. The mutations arose a median of 9.3 months prior to overt disease relapse, reported Jennifer A. Woyach, MD, of Ohio State University in Columbus, and colleagues.

medpagetoday.com/Hematology...

Neil

Photo: Seal Pup at Seal Bay, Kangaroo Island

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newyork8 profile image
newyork8

Even if the mutations are found early are there other treatments besides the ones we know about to deal with this? Isn't it still a choice of fcr br or idela or obin or venetoclax? Do we know which of these address certain mutations better than others?

Cllcanada profile image
CllcanadaTop Poster CURE Hero in reply to newyork8

No ... very early days on these mutations... still in the lab...

Still trying to expand the knowledge base...

~chris

db601 profile image
db601

Great photo - pure eye candy - thank your!

AussieNeil profile image
AussieNeilAdministrator

I see I've doubled up on an earlier posting by Cllcanada that can be found here: healthunlocked.com/cllsuppo...

Hoffy profile image
Hoffy

Thank you for a good article. I was treatment naïve now On imbruvica and will add Veneticlax soon but 17 P deleted so I will need to watch for this. I am on a clinical trial. Hopefully the combo therapy will knock down the disease so much that this will not be in issue.

It is good to know it can be seen early.

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