Hi everyone, I'm new to the community. My husband has CLL, just out of a 4 year remission post-FCR. His hemoglobin dropped in January to 8.5, has gone as low as 6.4 (for which he was hospitalized). He got 2 rounds of B+R, which shrunk his nodes right away but hgb remains hovering between 7-8, requiring weekly transfusions. The doctor switched him to ibrutinib which he started 2 weeks ago. He has also received weekly Procrit injections for the last month. Hgb hasn't budged yet. Based on the BMB results, the doctor doesn't believe this is aplasia and all other blood counts are now in the normal range. Labs don't indicate AIHA. We are stumped and frustrated and worried. I am counting on the ibrutinib to work its magic and clear out the bone marrow but I understand it doesn't necessarily happen right away?