The Cancer Network has reported research findings that mirror those found for CLL and Vitamin D:
' In patients with melanoma, lower 25-hydroxyvitamin D (vitamin D) levels were associated with poorer survival outcomes, according to a prospective study. This association was independent of C-reactive protein (CRP) levels.
“Vitamin D has anti-inflammatory properties, has antiproliferative effects on melanoma cells, can inhibit tumor growth and tumor invasiveness, and promotes melanoma cell DNA repair,” wrote study authors led by Jeffrey E. Lee, MD, of the University of Texas MD Anderson Cancer Center in Houston. Studies on intake or blood levels of vitamin D and melanoma risk, however, have yielded inconsistent results.
Several factors were significantly associated with vitamin D levels. They were higher when blood was drawn in the spring or summer compared to fall or winter (26.39 ng/mL vs 23.59 ng/mL; P < .001), and lower with increasing patient age and increasing CRP levels.
“The current investigation is the first, to our knowledge, to report a significant, independent association between lower vitamin D levels and poorer melanoma survival after adjustment for the influence of the [systematic inflammatory response] through simultaneous measurement of CRP,” the authors concluded. “A coordinated investigation of the mechanisms responsible for the independent association of these two important inflammatory biomarkers with outcomes in patients with melanoma is likely to be clinically relevant and may have implications for other cancers.” '
Interesting to note that lower vitamin D levels correlated with increasing CRP levels (with the latter an indication of inflammation or tumour activity). Obviously there's still a great deal we don't know about Vitamin D...