Chicken Pox Virus Reactivation ..

Anyone experienced reactivation Chicken Pox Virus aka Herpes Zoster .. This talk of Zika Virus being associated with Herpes Zooster & Chicken Pox Reactivation.

Could the chicken pox virus reactivation be causing new epidemic

ncbi.nlm.nih.gov/pmc/articl...

[Cllcanada Top Poster CURE Hero]

There is no association with Zika and chicken pox...Guillian-Barré syndrome is a rare neurological disorder that can be caused by many different kinds of infections...

the jury is still out on GBS...

~chd

[Hidden in reply to Cllcanada]

This lots of debate .. online communities with regard Zika and Hepes virus pathology Both virus are capable of passing threw placenta and do to babies humans what is happing.

The herpes zoster virus is highly infectious contagious resides in the ganglia like Zika virus

onlinelibrary.wiley.com/doi...

ncbi.nlm.nih.gov/pmc/articl...

[Cllcanada Top Poster CURE Hero in reply to Hidden]

One case study from 1987... GBS/Zoster reactivation... 😳

Many viruses live in us for life... Zoster is just one... it came down my trigeminal nerve and paralyzed the right side of my face... still is paralysed... I have PHN daily...wouldn't wish it on my worst enemy..

Zika gets transmitted sexually then there is worry...

~chris

[Hidden in reply to Cllcanada]

Was you never offerd zoster vacine and was that befour ccl diagnosis.

Zika is transmitted threw bites cdc.gov/zika/transmission/

Zoster chicken pox is contages person to person .. My post is not about genital herpes

health.ny.gov/diseases/comm...

[Cllcanada Top Poster CURE Hero in reply to Hidden]

There was no zostervax when I was diagnosed with CLL ...only about 50% effective anyways...

It was only approved for 50+ in 2011...

But never for CLL... live vaccine... !

[Cllcanada Top Poster CURE Hero in reply to Hidden]

I'm talking about ZIKA virus... has been reported transmitted sexually in Texas...

It has been found in semen as well...

[Hidden in reply to Cllcanada]

Is complex business as we all know saliva contains blood as few diagnostic test look for it.

Truth is there is going to lots of ways it's transmitted

[thegapwoman in reply to Hidden]

Typiclly the vaccine is not offered to people under the age of 65.

[Cllcanada Top Poster CURE Hero in reply to thegapwoman]

Location, location... but never for CLL patients..risk exceeds the benefit

Anyone aged 70 can have the shingles vaccine on the NHS. You become eligible for the vaccine from the first day of September after your 70th birthday for the following year.

nhs.uk/conditions/vaccinati...

[Psmithuk in reply to Cllcanada]

Sorry to hear this, Chris. You have a lot to put up with.

[hanskloss in reply to Cllcanada]

I have Herpes Zoster and also had a right face palsy last year while I was under FCR treatment. Doctors though it was from a tic bite but antibodies were never found anywhere including spine fluid...

I experience frequent sores on left ear - looks like that's where it likes to live and activate...

[Cllcanada Top Poster CURE Hero in reply to hanskloss]

Sounds like you had Ramsey-Hunt Type II, did you loose hearing, vertigo?

[hanskloss in reply to Cllcanada]

no , nothing like that. They still are not sure if the palsy was from neuroboreliosis, FCR or something else...the sores on the left ear pop up as soon as my body goes through some weakness it seems..

[AussieNeil Administrator]

Further to Chris's comments, according to Steven Maltby, Post-doctoral Fellow in Immunology & Genetics / Research Academic for CRE in Severe Asthma, University of Newcastle "It is important to note that it still has not been demonstrated that Zika infection actually causes Guillain-Barré syndrome. Further, even if all cases of Guillain-Barré syndrome reported in El Salvador were caused by Zika infection, only about one in 100 infected people develop Guillain-Barré syndrome. This ignores all of the cases due to other causes.

Causes

The exact cause of Guillain-Barré syndrome is still unclear, but it generally develops after a lung or gut infection and appears to be an autoimmune disease. This means that symptoms are caused by our own immune system attacking our body.

The initial infection can be caused by either bacteria or viruses, and a large number of infections have been linked to Guillain-Barré syndrome. The most commonly associated infections are the bacteria Campylobacter jejuni, cytomegalovirus and Epstein-Barr virus."

theconversation.com/explain...

Note the article you referenced states in the discussion section "Guillain-Barré syndrome following Herpes Zoster is rare. Since the first description in 1924, there have only been 24 reported cases."

Given that low historical occurrence, and Steven Maltby's statement "Further, even if all cases of Guillain-Barré syndrome reported in El Salvador were caused by Zika infection, only about one in 100 infected people develop Guillain-Barré syndrome. This ignores all of the cases due to other causes." that doesn't sound anything like an epidemic!

Also note Steven's statement "The most commonly associated infections (with Guillain-Barré syndrome - Neil) are the bacteria Campylobacter jejuni, cytomegalovirus and Epstein-Barr virus." Given how common chicken pox is, you would think it would be listed with ampylobacter jejuni, cytomegalovirus and Epstein-Barr virus if there was a strong association.

Neil

[Hidden in reply to AussieNeil]

Agree with pathology of both .. Truth is the don't really NO but both conditions have to much in common from virus pathology to symptoms

And CLL diagnoses plays a part in disease work up

[Cllcanada Top Poster CURE Hero in reply to AussieNeil]

I have always thought it was the other way around... GBS following Zoster reactivation... but very rarely.

cid.oxfordjournals.org/cont...

[Hidden in reply to Cllcanada]

Am no expert really just a suffer looking for answers .. But company that makes vacince for herpes zoster chicken pox

Is retrofitting vacine chicken pox vaccine for Zika ... I would like to see CDC tad more honest rather than worry bout cost inplacations of Chicken Pox Reactivation vaccine

[AussieNeil Administrator in reply to Hidden]

Jeff,

I can't see how the honesty of the CDC comes into question given world wide research. The real issue is that if there is any association, it's deeply buried in the 'noise' and extremely hard to identify.

I think your concerns are far, far greater than any real risk. If you are concerned about vaccinations for chicken pox possibly triggering GBS, given over 90% of people test positive for prior infection of Herpes Zoster, that's only going to increase the risk by 10% at most if 100% of the population are vaccinated.

And if you are worried about vaccinations against Zeka causing GBS, then I repeat Steve Maltby's comment above "Further, even if all cases of Guillain-Barré syndrome reported in El Salvador were caused by Zika infection, only about one in 100 infected people develop Guillain-Barré syndrome. This ignores all of the cases due to other causes." So that works out at less than 1% maximum, should the association be confirmed. Given El Savadorians would also be expected to develop GBS from prior infections by the recognised causes, it really makes the maximum possible number vanishingly small! About 80% of 80 year olds test positive for a previous Cytomegalovirus infection; I don't know the figures for Campylobacter jejuni and Epstein-Barr virus, but they would be considerable too.

There's no doubt that GBS is a serious disease that can have lifetime consequences and it's natural to want answers. At least with GBS, there's more certainty over what illnesses can trigger it than there is with CLL. The authors of the Oxford Journal paper Chris referenced don't seem to be convinced that there's a strong case for the varicella-zoster virus. From the discussion section of the paper: "Most importantly, is this evidence sufficient to add varicella-zoster virus (VZV) to the list of microorganisms that are known to trigger GBS?

Clinical and experimental studies in the past suggested a causal association between microbial organisms and the occurrence of GBS, on the basis of observations that symptomatic or inapparent infection with those agents often precedes the onset of GBS. The microbial organisms that have been linked most frequently to GBS patients are Campylobacter jejuni, Haemophilus influenzae, Mycoplasma pneumoniae, and cytomegalovirus (CMV). Very recent data indicate that influenza also precedes a substantial proportion of GBS cases.

:

Putting the data from Kang et al into this perspective makes it obvious that a temporal association per se does not necessarily mean a causal association. This is especially true for herpes zoster, because VZV shows profound differences in terms of epidemiology, pathogenesis, and host immunity, compared with other microbes known to trigger GBS. (My emphasis - Neil) The primary infection with VZV usually occurs during childhood, but VZV infection persists throughout an individual’s lifetime, because of the virus’ latency in ganglia of cranial nerves and of dorsal roots. More than 90% of adults in the United States and Europe have serologic evidence of prior VZV infection, and latent VZV is resident in the sensory ganglia of virtually every older adult. Herpes zoster results from reactivation of this latent VZV infection in a dermatomal distribution. In contrast, the infections that most commonly precede GBS occur sporadically and are self-limited because of a complete clearance by the host immune system. This does not exclude the possibility that VZV can cause GBS, but a state of latent persistence that alternates with periods of recrudescence is uncommon for infections that antedate GBS, except for CMV infection. Furthermore, it is assumed that herpes zoster is caused by a rogressive, age-dependent decrease of cellular immunity mainly mediated by CD4 memory T cells. In contrast, antibodies that are generated against VZV in the wake of the initial infection do not debase in titer and do not disappear during the persistent lifelong infection with VZV."

Neil

[Hidden in reply to AussieNeil]

Hi thanks for taking time to reply ... all very interesting stuff.

And that brings me to IGM antibodies .. You touched on it a tad when talking of clearance decreased numbers of antibodies.

So if you have decreased immunity threw Igm antibodies with NO know diagnostic cause found.

And you had chicken pox when a adult .. would you indeed be better of having herpes zoster vaccine no mater what your age is

[AussieNeil Administrator in reply to Hidden]

Herpes Zoster vaccine is a live vaccine so should not be given to CLL patients.

Neil

[Hidden in reply to AussieNeil]

So how would you fix it IF can't use live vaccines .. When we eat we are putting our selfs at risk from live cultures.

So the must be good and bad really or would it not be a contradiction.

Is it true that LOW IGM antibodes causes your blood cells to be very small & suffer from cell crowding

[AussieNeil Administrator in reply to Hidden]

All we can do is try and avoid infection and that includes avoiding live probiotic cultures if we are sufficiently neutropenic.

I've never heard of low IgM antibodies causing blood problems and how could it? If that were true, all babies would have that problem.

Neil

[Hidden in reply to AussieNeil]

IgM antibodies are mainly responsible for the clumping (agglutination) of blood cells

biology-pages.info/B/BloodG...

[AussieNeil Administrator in reply to Hidden]

That's one specific instance with the RH antibody. There are billions of possible antigens...