Dr. Keating's Crystal Ball on Immunoncology for CLL

[andrewschorr]

Here's my most recent video from last weekend's CLL Patient Advocacy Group meeting in Canada. Hear Dr. Michael Keating, CLL expert, discuss what could be the next wave in CLL treatment. patientpower.info/video/how...

[AussieNeil Administrator]

Thanks Andrew for putting this video on the possible next CLL treatment wave on your website so promptly.

Interesting to note that on the 30th of this month, Clinical Care Options have an evening CME-Certified Educational Event on Immune Checkpoint Inhibitors at the Hyatt Rgency in Chicago:

Agenda

* What Are the Expected Benefits of Immune Checkpoint Inhibitors and How Do We Get There?

* What Are the Potential Adverse Events of Immune Checkpoint Inhibitors and How Do We Manage Them?

* Immune Checkpoint Inhibitors: Who Will It Help?

* On the Horizon: Future Developments and Novel Immune Checkpoint Blockade Strategies

I expect that the presented material will eventually be made available as a web based educational resource and registration with clinicaloptions.com is free - you don't have to have medical qualifications to join.

Will Dr Keating be right? "So I think that this is probably going to be the most exciting 12 months in immuno- oncology area in CLL." and will we be able to side - step CAR-T technology and jump right to inducing our T-cells to be active against cancer cells using already available antibodies against these checkpoint inhibitors?

It will be very interesting to look back in May 2016 and see if we have a new protocol based on checkpoint inhibitor antibodies to achieve a magnitude or more deeper Minimal Residual Disease levels and thereby even a cure for CLL, perhaps in conjunction with existing protocols.

Neil

[Justasheet1]

Dr Keating has such a calming effect on me. He seems like a wonderful person as well as a great doctor.

Jeff

[andrewschorr in reply to Justasheet1]

He's been calming ME for 19 years!

[AussieNeil Administrator]

And in related news, from April 2015 Hematology Times: 'Researchers say they have uncovered a mechanism that could aid the development of therapies for lymphomas and leukemias.

The group’s research shed new light on a mechanism affecting activation-induced deaminase (AID), an enzyme that has proven crucial for immune response.

Javier Di Noia, PhD, of Institut de Recherches Cliniques de Montreal (IRCM) in Quebec, Canada, and his colleagues described this mechanism in The Journal of Experimental Medicine.

Dr Di Noia noted that, although AID is crucial for an efficient antibody response, high levels of the enzyme can have harmful effects and lead to cancer-causing mutations.

“The objective is to find the perfect level of AID activity to maximize the protection it provides to the body while reducing the risk of damage it can cause to cells,” he said.':

hematologytimes.com/p_artic...

[jangreen]

Hi yes keep doing what you do. Many thanks and best wishes