CLL Support Association
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Has anyone experienced extreme stomach upset on Ibrutinib?

After more than three months on Ibrutinib, I started having extreme stomach upset such as burning sensation and extreme heat in my stomach. A recent endoscopy confirmed the irritated lining of my stomach and redness. I was wondering if anybody else has experienced the same discomforts? Otherwise, Ibrutinib is doing a wonderful job.

4 Replies

Gastrointestinal disorders have been reported by a number of patients, you need to work with your doctor to perhaps change how you are taking it, vary dose etc...

Drug label with side effects


Thanks for your reply. Well, I called Pharmacyclics (maker of Ibrutinib) they said only 13% of the patients in clinical trials showed signs of DYSPEPSIA (indigestion...). But, they never had a report of any symptoms such as mine (REACTIVE GASTROPATHY). I called the oncologist office but he is too busy to see me. What a joke, I am suffering and he is busy making money.


It's July '16 -- and i've been having similar symptoms....How are you doing now?

Did they change your dose, or recommend a best time to take the meds?


Hi Suz. Sorry for getting back to you late. I do feel better now but I still have some stomach issues with Imbruvica. First they reduced my dose to two but after two months I went back to three a day. I did an endoscopy and it confirmed my irritations. My gastroenterologist put me on Misoprostol (200mcg) four times a day (before each meal and at the bed time). Now, I only take one in the morning.

From what I have read and learned most stomach issues related to Imbruvica go away after a while. All my life I had to struggle with stomach problems (acid reflux, ulcer...) so my case is probably a rare situation. I have been on acid reflux meds all my adult life. Now, I take Nexium 40mg and Misoprostol 200mcg in the morning before breakfast. After a light breakfast I take Imbruvica (3 capsules) with at least 16oz of water. I drink clean water (not tap water). I don't drink coffee or tea until 4-5 hours passed taking Imbruvica. I do drink plenty of water during the day and I am sure that is what has helped me a lot with my stomach flare ups. They recommend if any med upsets stomach to take it with food. I also found out that starch foods (mashed potatoes, simple white bread, plain rice....) help me a lot with stomach problems. I don't eat anything spicy or acidic (lemonade, lime juice...).

I hope these info help you in some ways. Please let me know if you have any specific question. Also, I suggest to see a gastroenterologist and find out if endoscopy is necessary in your case. Take good care.


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