Did anyone have MGUS progress into CLL, and after treatment for CLL, did your MGUS improve or no longer exist?

[Luv2Craft]

Hi I'm new to the CLL community. My name is Vicki. I was diagnosed with M.G.U.S. (Monoclonal Gammopathy of Undetermined Significance) 15 years ago. It is an abnormal protein (M protein) in the blood and a precancerous condition to Multiple Myeloma, Lymphoma, CLL etc.

I was diagnosed in October 2021 with CLL, and will be starting treatment with Acalabrutinib in two weeks.

I asked my doctor if Acalabrutinib would treat both my CLL and MGUS. He said CLL makes the MGUS protein and that the treatment should apply to both conditions. He seemed unsure of his answer and said he would include MGUS on future lab testing and then we will know if the abnormal protein (M Protein)/MGUS in my blood is affected by Acalabrutinib.

My questions are:

1. Has anyone been diagnosed with MGUS that progressed into CLL?

2. After treatment for CLL did your MGUS labs improve...for example, your IgA, IgM or M-Spike?

[Skimom]

You might want to re ask your question in the Cll support group. They are a multi national support group here. The US group is inactive.

[Luv2Craft in reply to Skimom]

Thanks Skimom. I reposted my question in the CLL Support group as you suggested. I appreciate your help 😀