As most of you know by now I gave a talk yesterday to a group of Doctor's , in general the talk went well. However I was asked a lot of questions for my final word I asked them one question. PBC is mainly associated with females, when a male gets PBC it seems to advance towards a TX quicker WHY.?. My theory is the difference in hormones. From diagnosis to TX my time was 2yrs 6months. I left the room with a group of Doctors being silent but scratching their heads... have a good day every one..